摘要
目的：分析血清胱抑素C（Cyst—C）水平与急性脑梗死神经功能缺损严重程度的关系。方法：选择皖南医学院弋矶山医院神经内科2010年12月到2011年7月住院治疗的急性脑梗死患者398例，于人院后次晨测定血清Cyst—C，同时采用美国国立卫生研究院卒中量表（NIHSS）对患者入院时神经功能缺损程度进行评分。将患者分为轻度神经功能缺损（NIHSS〈4分）、中度神经功能缺损（NIHSS评分4～15分）、重度神经功能缺损（N1HSS评分〉15分），比较各组『HJ血清Cyst—C水平的差异，并分析神经功能缺损程度的相关因素。结果：轻度神经功能缺损152例，平均NIHSS为2．45分，中度神经功能缺损186例，平均NIHSS为10．05分，重度神经功能缺损60例，平均NIHSS为18．09分。轻度神经功能缺损血清Cyst—C水平0．93±0．46mmol／L，中度神经功能缺损血清Cyst—C水平1．13±0．35mmol／L，重度神经功能缺损m清Cyst—C水平1．43±0．75mm01／[。。神经功能缺损程度越重，血清Cyst—C水平越高，组问差异有统计学意义（P〈0．05），进一步行SNK—q检验，3组间两两比较，差异有统计学意义（P〈0．05），神经功能缺损程度与血清Cyst—C水平呈止相父（r=0．041，P〈0．01）。结论：血清Cyst—C水平与急性脑梗死的神经功能缺损程度相关。血清Cyst—C是急性脑梗死的独立危险因素，也是对脑梗死后神经功能缺损程度预后的预测指标之一。治疗高血清Cyst—C血症既可以预防脑梗死，又对改善脑梗死预后起到重要的作用。
OBJECTIVE ： To analyze the relationship between serum Cyst - C level and dysneuria tollowing acute cerebral infarction. METHODS： 398 patients after acute cerebral infarction were selected from the department of neurology. Cyst - C level was measured the next morning and dysneuria was scored by NIHSS. Then the patients were divided into 3 groups ： the light group （ NIH- SS 〈4, n = 152）, the moderate group （ NIHSS 4 - 15, n = 186） and the severe group （ NIHSS 〉 15, n =60）. The Cyst - C levels in three groups were compared. Related factors of this disease were analyzed at last. RESULTS ： Average NIHSS score in light group was 2.45 and the Cyst - C level was 0. 93 ± 46mmol/L. Average NIHSS score was 10. 05 and the Cyst - C level was 1.13 ± 0. 35mmol/L. NIHSS score in the severe group was 18.09 （ 1.43 ±0. 75） mmol/L and the serum Cyst - C level was raised with neu- rological impairment （P 〈 0. 05 ）. The degree of neurological impairment was positive correlation with the serum Cyst- C level （r = 0. 041, P 〈 0. 01 ）. CONCLUSIONS： The study suggests that the degree of dysneuria is related with serum Cyst - C level, which in- dicates that Cyst - C level is independently the risk factor of the acute cerebral infarction and one of the predicting index of dysneuria. So Reducing elevated serum Cyst - C levels may prevent acute cerebral infarction and improve the prognosis of it.
出处
《国际老年医学杂志》
2012年第3期102-105,共4页
International Journal of Geriatrics
关键词
脑梗死
胱抑素C
神经功能缺损
Cerebral infarction
Cyst - C
Neurologic deficits
