摘要
目的分析静脉输液引起的不良反应及对策。方法从查阅1979—2011年万方期刊全文数据库中公开发行的医学期刊中筛选、归类、讨论与分析。在2011-10-13百度搜索"输液"及"死亡"相关新闻72400篇,经筛选与输液死亡相关的案例合并进行统计分析。结果 15篇文献报道2497例输液不良反应涉及的药物种类,15篇文献报道95例输液不良反应的临床症状,新闻报道112例输液死亡。儿童发生不良反应高达40.2%;输液过程中出现不良反应药物中,抗生素所致不良反应占45.7%,不良反应临床表现以热原反应为主;感冒、咳嗽等上呼吸道感染疾病输液引起死亡的发生率高达58.0%。每年第三季度发生的输液不良反应占42.7%。结论儿童、抗生素治疗、呼吸道感染以及每年第三季度是输液不良反应的危险因素,应谨慎选择输液,减少输液不良反应的发生。
ObjectiveIntravenous infusion is overused in China's Mainland.This study was conducted to investigate the characterization of adverse events and deaths induced by intravenous infusion.MethodsWe used key words ＂intravenous infusion＂ AND ＂adverse event＂ to search clinical reports from the databases CNKI and Wang Fang between 1979 and 2011.Key words ＂intravenous infusion＂ AND ＂death＂ were used to search engine ＂baidu.com＂ accessed on 13 December 2011.ResultsThere were 2479 adverse events and 112 intravenous infusion-induced death cases released from news media.The adverse events occurred predominantly in children（40.2%） and in the 3rd season（42.7%）.Antibiotics accounted for 45.7% of the prescribed drugs and upper airway infection was the most common indication（58.0%）.There was 10-fold of increase in the infusion-mediated death between 2007 and 2011.ConclusionChildren,antibiotics,upper airway infection and the 3rd season are the risk factors of intravenous infusion-mediated adverse events and deaths.Caution should be taken when using intravenous infusion.
出处
《临床合理用药杂志》
2012年第15期7-10,共4页
Chinese Journal of Clinical Rational Drug Use
基金
桂林医学院高级人才引进基金(KY2011002)
广西科技厅重点实验室培育项目(SYS2011003)
关键词
输液
儿童
抗生素
不良反应
死亡
Intravenous infusion
Children
Antibiotic
Adverse event
Death
