摘要
目的 探讨慢性硬膜下血肿 (CSDH)液中纤维蛋白溶解特征及其与再出血的关系。 方法 将 31例CSDH患者按照CT表现分为等、低、混合性和分层状密度 4类 ,采用电泳法和免疫染色法对血肿液中纤维蛋白原、纤维蛋白单体和D -二聚体进行测定。 结果 纤维蛋白原浓度在等密度血肿中为 (78± 14)mg L ,低密度中为 (14± 6 )mg L ,混合性密度中为 (16 0± 36 )mg L ,分层状密度中为 (15 9± 2 9)mg L ;纤维蛋白单体在 4类血肿中的浓度分别为 (780± 2 40 ) ,(180± 80 ) ,(182 0± 46 0 )和 (1840± 2 70 ) μg L ,D -二聚体的浓度分别为 (12 10± 186 ) ,(2 81± 15 2 ) ,(1139± 194)和 (196 2± 32 4)mg L。 结论 混合性和分层状CSDH腔内纤维蛋白溶解活性高 ,有较明显的再出血趋势。
Objective [WT5”BZ]To study the characteristics of fibrinolysis in chronic subdural hematomas (CSDH) and its relationship with local rebleeding. [WT5”HZ]Methods [WT5”BZ] CSDH were divided into four types according to their appearance on computerized tomography: isodensity, low density, mixed density and layering types. And the fibrinogen, fibrin monomer and D dimer in CSDH were analyzed with SDS PAGE and immunoblotting. [WT5”HZ] Results [WT5”BZ] The concentration of fibrinogen was (78±14) mg/L in the isodensity type, (14±6) mg/L in the low density type, (160±36) mg/L in the mixed density type ,and (159±29) mg/L in the layering type. The concentration of fibrin monomer were (780±240) μg/L,(180±80) μg/L,(1 820± 460) μg/L and (1 840 ±270 ) μg/L in the isodensity, low density, mixed density and layering types of hematomas, respectively. The D dimer was (1 962±324) mg/L in the layering hematomas,(281±152) mg/L in the low density ones, (1 210 ±186)mg/L in the isodensity ones ,and (1 139±194) mg/L in the mixed density ones. [WT5”HZ] Conclusions [WT5”BZ] The hyperfibrinolytic activity is high and has a high tendency to rebleed in the layering and mixed density hematomas.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2000年第6期362-363,共2页
Chinese Journal of Trauma
关键词
硬膜下血肿
纤维蛋白溶解
脑出血
WT5”BZ] Hematoma, subdural
Fibrinolyses
Cerebral hemorrhage
