摘要
目的观察分析单采血小板在保存期间各项指标的改变,探讨储存损伤对血小板的影响。方法检测单采血小板22℃震荡保存1、3、5、7 d的MPV、PDW、PLT、活化率和血浆中S1P浓度。结果随保存时间的延长,单采血小板保存期间MPV和PDW升高,PLT下降,活化率增高,血浆中S1P浓度上升。结论血小板在保存期间发生一定程度的活化,甚至凋亡,说明储存损伤影响了血小板质量,并有可能影响临床输注效果。
Objective To observe and analyze the changes of indicators of apheresis platelets during storage and to explore the impact of shake storage damage on platelet.Methods MPV,PDW,PLT,activation rate and plasma S1P concentration of apheresis platelet 1,3,5 and 7 days after shake storage at 22 °C were detected.Results With the extension of storage time,MPV and PDW increased,PLT gradually decreased,activation rate and plasma S1P concentration increased.Conclusion Platelet is activated to a certain extent,or even resulted in apoptosis during storage,which indicates that storage affects the quality of the platelets and thus may affect clinical transfusion effect.
出处
《中国医药导报》
CAS
2012年第13期86-87,共2页
China Medical Herald
