期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

胰岛素样生长因子-1与胎儿生长发育关系的研究 被引量：2

原文传递
导出
摘要 胎儿宫内的生长发育受多种因素影响，包括遗传、营养、生长激素及环境等方面。尽管进行了广泛的研究，胎儿生长发育中起重要作用的内分泌机制仍未完全阐明。胰岛素样生长因子-1（insulin-likegrowthfactor-1，IGF-1）是由70个氨基酸组成的单链碱性蛋白，具有胰岛素样生物活性，参与糖、脂肪、蛋白质的代谢，并可促进细胞增殖分化，抑制细胞凋亡。近年来研究发现IGF-1是妊娠早期胚胎发育的重要调节因子之一，并推测其可能参与妊娠中晚期胎儿生长发育的调节。本研究通过对母体血清中IGF-1的含量、胎儿脐血以及胎盘组织中IGF-1mRNA和蛋白的表达量进行测定，以进一步探讨IGF-1与胎儿生长发育的关系。
作者 刘亚军 陈维萍 彭伟 叶元华
机构地区 青岛大学医学院附属医院产科
出处 《中华围产医学杂志》 CAS 北大核心 2012年第5期288-290,共3页 Chinese Journal of Perinatal Medicine
关键词 胰岛素样生长因子-1 胎儿生长发育 IGF-1mRNA 妊娠中晚期 细胞增殖分化 早期胚胎发育 碱性蛋白 调节因子
分类号 R714.5 [医药卫生—妇产科学]
  • 相关文献

参考文献15

  • 1Freese LG, Rehfeldt C, Fuerbass R, et al. Exogenous somatotropin alters IGF axis in porcine endometrium and placenta. Domest Anita Endocrinol, 2005,29:457-475.
  • 2Harvey MB, Kaye PL. Mouse blastocytes respond metabolicallyto short-term stimulation by insulin and IGF-1 through the insulin receptor. Mol Reprod Dev, 1999,29 : 253-258.
  • 3Saylan F, K6ken G, Cosar E, et al. Maternal and fetal leptin and ghrelin levels: relationship with fetal growth. Arch Gynecol Obstet, 2011, 284: 327-329.
  • 4刘虹,梁雪雯,王彦德.瘦素及胰岛素样生长因子-Ⅰ与胎儿生长受限的关系[J].中国实用妇科与产科杂志,2004,20(6):361-362. 被引量：19
  • 5Boyne MS, Thame M, Bennett FI, et al. The relationship among circulating insulin-like growth factor (IGF)-I , IGF binding proteins-1 and -2, and birth anthropometry: a prospective study. J Clin Endocrinol Metab, 2003,88: 1687- 1691.
  • 6Mantzoros CS. The role of leptin in human obesity and disease : a review of current evidence. Ann Intern Med, 1999, 130:671-680.
  • 7Lee MH, Jeon YJ, Lee SM, et al. Placental gene expression is related to glucose metabolism and fetal cord blood levels of insulin and insulin like growth factors in intrauterine growth restriction. Early Hum Dev,2010,86:45-50.
  • 8DavidsonS, Hod M, Merlob P, et al. Leptin, insulin, insulin-like growth factors and their binding proteins in cord serum: insight into fetal growth and discordancy. Clin Endocrinol(Oxf), 2006,65 : 586-592.
  • 9吴琦嫦,刘运科,刘 斌.胰岛素样生长因子1及胰岛素样生长因子结合蛋白3与胎儿生长发育的关系[J].现代妇产科进展,2002,11(3):206-208. 被引量：9
  • 10Chetty A, Nielsen HC. Regulation of cell proliferation by insulin-like growth factor 1 in hyperoxia-exposed neonatal rat lung. Mol Genet Metab,2002,75:265-275.

二级参考文献12

  • 1李世娟.胎儿宫内生长延缓.临床产科学[M].天津:天津科技出版社,2000.231.
  • 2乐杰.妇产科学（第5版）[M].北京:人民卫生出版社,2002.112.
  • 3Low JA,Handley-Derry MH,Durke SO,et al.Association of intrauterine fetal growth retardation and learning deficients at age 9 to 11 years.Am J Obstet Gynecol,1992,167(6):1499-1503
  • 4Carro E,Senaris R,Considine RV,et al.Regulation of in vivo growth secretion by leptin.Endocrinology,1997,138(5):2203-2205
  • 5Mise H,Sagawa N,Matsumoto T,et al.Augmented placental production of leptin in preeclampsia:possible involvement of placental hypoxia.J Clin Endocrinol Metab,1998,83(9):3225-3228
  • 6Tamura T,Coldenberg RL,Johnston KE,el al.Serum leptin concentrations during pregnancy and their relationship with fetal growth.Obstet Gynecol,1998,91(3):389-392
  • 7Arosio M,Cortetazzi O,Perani L,et al.Circulation levels of growth hormone,insulin-like growth factor-1 and prolactin in normal,growth retarded,and anencephalic human fetuses.J Endocrinol Invest,1995,18(2):346-350
  • 8Toprak D, Gokalp AS, Hatun S, et al. Serum leptin levels of premature and full-term newborns in early infancy: metabolic catch-up of premature babies. Turk J Pediatr, 2004, 46: 232-238.
  • 9Chen X, Lin J, Hausman DB, et al. Alterations in fetus adipose tissue leptin expression correlate with the development of adipose tissue. Biol Neonate, 2000,78:41-47.
  • 10Alavi K, Schwartz MZ, Prasad R, et al. Leptin: a new growth factor for the small intestine. Pediatr Surg, 2002,37:327-330.

共引文献25

同被引文献25

二级引证文献5

中华围产医学杂志
2012年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部