摘要
目的 评价维持量地高辛间歇疗法治疗窦性心律心力衰竭的临床疗效。方法 113例窦性心律心力衰竭患者随机分为二组 :A组 :5 6例采用间歇维持量地高辛治疗 ;B组 5 7例采用持续维持量地高辛治疗。结果 两组患者治疗前与治疗 3个月和 8个月比较左心室射血分数 (LVEF ,A组分别为 0 3 6± 0 12 ,0 4 2± 0 11,0 4 4± 0 14 ;B组分别为 0 3 6± 0 15 ,0 4 3± 0 13 ,0 4 5± 0 15 ) ,心室率(HR ,次 /min ,A组分别为 98± 15 ,76± 16,74± 14 ;B组分别为 10 0± 12 ,75± 12 ,75± 16)治疗后与治疗前比较差异均有显著性 (P <0 0 1) ,二组间比较差异无显著性 (P >0 0 5 ) ;地高辛过量或中毒的发生率两组差异有显著性 (P <0 0 1)。结论 间歇维持量地高辛疗法可降低洋地黄过量或中毒的发生率 ,其疗效相似 ,可能是一种安全有效的临床给药方法。
Objective To study the effects of intermittent maintenance digoxin therapy in congestive heart failure with sinus rhythm. Methods One hundred and thirteen congestive heart failure patients with sinus rhythm divided into group A (56 cases with intermittent maintenance digoxin treatment) and group B (57 cases with continuous maintenance digoxin treatment) were observed for 8 months. Results As compared with the pretreatment data, left ventricular ejection fraction (LVEF) and heart rate (HR) (LVEF 0 36±0 12 vs 0 42±0 11 and 0 44±0 14 in group A, 0 36±0 15 vs 0 43±0 13 and 0 45±0 15 in group B; HR 98±15 vs 76±16 and 74±14 in group A, 100 ±12 vs 75±12 and 75±16 in group B, respectively) were significantly improved ( P< 0 01) at the 3rd and 8th month of treatment. The total occurrence rate of digoxin overload or toxication in group A was significantly lower than those in group B (3 6% vs 12 3%, respectively ( P< 0 01). Conclusion Intermittent maintenance digoxin treatment in congestive heart failure with sinus rhythm is effective and safe, with a lower digitalis toxication occurrence compared with continuous maintenance digoxin treatment.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2000年第1期56-57,共2页
Chinese Journal of Cardiology
