摘要
目的:探讨新生儿化脓性脑膜炎早期诊断治疗方法。方法:对38例新生儿化脓性脑膜炎患儿的临床资料进行回顾性分析。结果:新生儿化脓性脑膜炎临床特征多有发热、拒奶或呕吐、黄疸、前囟改变、肌张力升高等,血白细胞、CRP呈现动态变化,脑脊液检查以白细胞及蛋白升高、糖降低为主。病原菌主要是葡萄球菌、大肠埃希菌、无乳链球菌。结论:新生儿化脓性脑膜炎的早期识别有赖于细致的临床观察,及时的脑脊液检查,合理应用抗生素是治疗关键。
Objective： Aim To investigate methods of early diagnosis and treatment of neonatal bacterial meningitis （NM）. Methods：A retrospective study of neonates with bacterial meningitis was made. Results： Clinical features included fever, reduced feeds or vomiting, jaundice, bulging fontanel, tone up. Increase of WBC and CRP were shown in most cases. CSF parameters were elevation of WBC and protein, decrease of glucose. The 3 major pathogens were Staphylococcus, E. coli and Streptococcus agalactiae. Conclusions ： Signs and symptoms of NM may be subtle, unspecific. The early diagnosis depends on familiarity with evidence underscoring clinical features and prompt lumbar puncture. When NM is suspected, antibiotics .treatment must be aggressive and as soon as possible.
关键词
化脓性脑膜炎
新生儿
诊断
治疗
Bacterial meningitis
Neonate
Diagnosis
Treatment
