摘要
目的:探讨参七脉心通胶囊对急性心肌梗塞(AMI)患者炎症因子的影响。方法:入选我院心内科住院,且确诊为AMI患者50例,随机分为两组:甲组:阿司匹林组25例,乙组:阿司匹林加参七脉心通胶囊组25例,分别测定两组用药前、后血清高敏C-反应蛋白(hs-CRP)、可溶性细胞间粘附分子-1(SICAM-1)水平,并作对比分析,另外选择我院健康体检者25例为丙组(正常对照组)。结果:治疗前甲组、乙组较丙组hs-CRP[(9.98±1.00)mg/L;(10.33±0.79)mg/L;(0.81±0.20)mg/L]、SICAM-1[(443.73±20.79)ng/ml;(458.30±28.26)ng/ml;(121.22±15.95)ng/m1]水平显著升高(P<0.01)。治疗7d后,甲组、乙组较治疗前hs-CRP[(6.69±0.73)mg/L;(9.98±1.00)mg/L;(5.20±0.76)mg/L;(10.33±0.79)mg/L]、SICAM-1([273.71±12.48)ng/ml;(443.73±20.79)ng/ml;(231.80±21.13)ng/ml;(458.30±28.26)ng/m1]水平显著下降(P<0.01),且乙组下降更显著(P<0.05)。结论:参七脉心通胶囊可减轻动脉炎症反应,具有抗炎作用。
[ Abstract] Objective： To explore the effect of Shenqi Maixintong capsule on levels of inflaalamatory factors in patients with acute myocardial infarction （AMI）. Methods： 50 patients who were diagnosed as AMI in our hospital were enrolled in the study. They were randomly divided into two groups： Group A （aspirin group, n=25）, group B （aspirin plus Ginseng seven veins heart group, n=25）. Another 25 normal persons were regard as normal control group. Levels of serum high sensitive C-reactive protein （hs-CRP） and soluble intercellular adhesion molecules-1 （SICAM-1） were measured in three groups before and after treatment. The results were compared and analyzed later among three groups. Results： Before treatment, the hs-CRP levels in group A,B [（9.98±1.00） mg/L, （10.33 ±0.79）mg/L] significantly increased than that of group C [（0.81±0.20）mg/L], the SICAM-1 levels in group A, B [（443.73±20.79） ng/ml, （458.30±28.26） ng/m 1 ] also significantly increased compared with C group [（121.22±15.95）ng/m 1 ] （P〈0.01） all. After treatment 7 days, levels of hs-CRP in group A, B [（6.69 ±0.73） mg/L, （5.20 ± 0.76） rag/L] significantly decreased than before treatment [（9.98±1.00） mg/L, （10.33 ± 0.79） mg/L], and SICAM-1 levels in group A, B [（273.71 ±12.48） ng/ml, （231.80±21.13） ng/ml] significantly decreased compared with before treatment [（443.73±20.79） ng/ml, （458.30±28.26） ng/ml] （P〈0.01）, and it＇s more significant in group B （P〈0.05）. Conclusions： The results suggest Shenqi Maixintong capsul can reduce artery inflammatory reaction, has possesses anti-inflammatory function.
出处
《中医临床研究》
2012年第9期8-10,共3页
Clinical Journal Of Chinese Medicine
关键词
心肌梗塞
参七脉心通胶囊
C反应蛋白质
细胞粘附分子
Myocardial infarction
Shenqi Maixintong capsule
Creactive protein
Cell adhesion molecule
