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B6. MRL-Fas^(lpr)/J狼疮小鼠脾脏组织中Th17细胞比例及其与病情的相关性 被引量：1

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摘要 目的探讨Th17细胞在系统性红斑狼疮发生、发展中的作用。方法观察组为B6.MRL-Faslpr/J(简称B6.Fas)狼疮小鼠9只,对照组为雌性C57BL/6J小鼠6只。采用流式细胞术检测两组脾脏组织匀浆中的Th17细胞比例;采用ELISA法检测血清IL-17A、ANA及dsDNA抗体水平,磺基水杨酸—硫酸钠比浊法检测小鼠24 h尿蛋白量;分析观察组各指标间的相关性。结果观察组Th17细胞比例、IL-17A、ANA、dsDNA抗体水平及24 h尿蛋白量均明显高于对照组,P均<0.05;观察组脾脏Th17细胞比例与血清IL-17A、ds-DNA抗体及24 h尿蛋白量呈正相关,与血清中ANA无明显相关性;IL-17A水平与血清中ds-DNA及24 h尿蛋白量呈正相关,与血清ANA无明显相关性。结论 Th17细胞可能与狼疮的发病及病情活动、肾脏损害有一定相关性。
作者 黄翠丽 林有坤 张力丹 罗彦彦 刘慧
机构地区 广西医科大学第一附属医院
出处 《山东医药》 CAS 2012年第19期25-27,共3页 Shandong Medical Journal
基金 广西青年科学基金资助项目(桂科青0542055) 广西卫生厅重点课题(桂卫重200829) 广西卫生厅自筹课题资助项目(桂卫z2001048) 广西2009研究生创新计划资助项目(309232)
关键词 B6.MRL-Faslpr/J狼疮鼠 Th17细胞 白细胞介素-17
分类号 R751 [医药卫生—皮肤病学与性病学] R392.12 [医药卫生—免疫学]
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参考文献9

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二级参考文献13

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山东医药
2012年 第19期

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