大功率微波热疗联合希罗达、奥沙利铂治疗晚期胃癌被引量：2

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摘要目的观察大功率微波热疗联合希罗达、奥沙利铂治疗晚期胃癌近期疗效及副作用。方法共收录晚期胃癌患者28例,其中男15例,女13例,年龄35～68岁,平均年龄48.6岁。28例均为晚期胃癌,所有病例中24例有病理证实,并有明确的可测病灶。4例无病理证实,但有明确可测病灶。卡氏评分≥40分,预计生存期≥3个月,既往化疗18例,其中有8例含有奥沙利铂,所有病例均未应用希罗达化疗。化疗前查血常规、肝肾功能均正常,并均征求患者同意。结果每例患者完成3～4周期化疗后评价。5例达CR,11例达PR,9例达SD,3例达PD,有效率(CR+PR)达57.1%,中位缓解期10月,中位生存期13.2月。毒副反应主要表现为胃肠道毒性、血液毒性、外周神经毒性及手足综合征,且均为Ⅰ～Ⅱ度,对治疗无影响;大功率微波热疗治疗后部分病例不同程度出现局部皮肤红肿,次日均恢复正常,不影响治疗。结论大功率微波热疗联合希罗达、奥沙利铂治疗晚期胃癌疗效较好,耐受力好,无严重不良副反应,适用于临床治疗。

作者徐世明刘燕张晓梅李军凯孔凡君许文

机构地区济南军区第四五六医院肿瘤科广州解放军军事体育进修学院干休所

出处《中国实用医药》 2012年第11期172-173,共2页 China Practical Medicine

关键词微波热疗胃癌化疗

分类号 R735.2 [医药卫生—肿瘤]

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