摘要
为探讨血管紧张素Ⅱ特异性受体 1阻滞剂氯沙坦对血浆血管紧张素Ⅱ及胸主动脉内皮功能的影响 ,腹腔注射链脲佐菌素复制大鼠糖尿病模型 ,分别于第 4、8、16周处死动物 ,取胸主动脉环测定乙酰胆碱引起的内皮依赖性舒张反应 ,并测定血浆血管紧张素Ⅱ浓度。结果发现 ,糖尿病大鼠随病程进展 ,其胸主动脉环乙酰胆碱引起的内皮依赖性舒张反应渐进性下降 ,血浆中血管紧张素Ⅱ浓度升高。提示 ,氯沙坦可明显改善内皮依赖性舒张反应 ,但对血浆血管紧张素Ⅱ浓度无降低作用。
Aim The previous studies have demonstrated that the acetylcholine(Ach)-induced endothelium cells(EC)-dependent relaxation were injuried in diabetic models. The present study was to investigate the effect of Losartan, a specific inhibitor of angiotensin Ⅱ (Ang Ⅱ) receptor 1 (AT 1), on dysfunction of EC-dependent relaxation in diabetic rats induced by streptozotocin(STZ) at different time. Methods The Ach-induced EC-dependent relaxation of rat aortic rings were tested in tissue bath, the concentration of plasma glucose and Ang Ⅱ were measured. Results At 4 weeks, the function of EC-dependent relaxation was not injuried in diabetic group, but the concentration of plasma glucose and Ang Ⅱ were increased significantly compared with control group. The percent of Ach-induced relaxation was declined obviously compared with control group at 8, 16 weeks. Treatment with losartan significantly protected the function of EC-dependent relaxation, the percent of Ach-induced relaxation was obviously increased compared with diabetic group. The concentration of plasma glucose was not changed , but the plasma Ang Ⅱ was increased compared with diabetic group. Conclusion Losartan could protect the function of EC-dependent relaxation in diabetic rats.
出处
《中国动脉硬化杂志》
CAS
CSCD
2000年第1期35-38,共4页
Chinese Journal of Arteriosclerosis
