摘要
目的 :评价复方丹参气雾剂合用硝酸甘油治疗冠心病心绞痛的疗效。方法 :将 90例冠心病心绞痛患者随机分为 3组 :A组 30例给予复方丹参气雾剂 ;B组 30例给予复方丹参气雾剂 ,另加硝酸甘油静滴 ;C组单用硝酸甘油静滴。观察治疗前后 3组疗效 (心电图和症状 ) ,并观察 A、B组血液流变学改变 ,B、C组硝酸甘油用量。结果 :A组症状及心电图总有效率分别为 76 .7%和 46 .7% ;C组症状及心电图总有效率分别为 73.3%和43.3% ,2组比较差异无显著性 (P均 >0 .0 5 ) ;B组症状及心电图总有效率分别为 96 .7%和 6 0 .0 % ,均优于上述 2组 (P均 <0 .0 5 )。A组、B组治疗前后血液流变学有显著改善 ,且 B组与 A组有显著差异 (P<0 .0 5或 P<0 .0 1)。B组硝酸甘油用量显著少于 C组 (P<0 .0 5 )。结论 :复方丹参气雾剂是治疗冠心病心绞痛的有效药物 ,与硝酸甘油合用可增强疗效 ,且能减少硝酸甘油用量 ,抑制其不良反应。
Objective:To evaluate the curative effect of composite salvia miltiorrhiza bunge complex aerosol (SMBC) on ischemic angina pectoris.Methods:90 cases with ischemic angina pectoris were randomly divided into three groups,the patients of group A were administered SMBC;the patients of group B were administered the mentioned SMBC and nitroglycerin;the patients of group C were administered nitroglycerin.The curative effect (ECG and symptom) of three groups was contrasted and observed before and after treatment;the alteration of hemorrheology of group A and group B,and the dosage of nitroglycerin of group B and group C were observed.Results:The total effective rate of symptom(76 7% vs.73 3%) and ECG(46 7% vs.43 3%) in group A and group C were similiar (all P>0 05),the curative effects(96 7% and 60 0%,respectively) in group B significantly higher than group A and group C(all P<0 05).The alteration of hemorrheology of group A significantly more than group B (P<0 05 or P<0 01).The dosage of nitroglycerin in group B was markedly lower than group C(P<0 05).Conclusions:SMBC is an effective drug for ischemic angina pectoris.Combine with SMBC and nitroglycerin can enhance curative effect and decrease the dosage of nitroglycerin and can inhibit the deleterious effect of nitroglycerin.
出处
《中国中西医结合急救杂志》
CAS
2000年第2期69-70,共2页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
国家中医药管理局!2000C1 课题临床科研协作项目
山东省兖州市科研项目
关键词
心绞痛
冠心病
复方丹参气雾剂
硝酸甘油
治疗
angina pectoris
salvia miltiorrhiza bunge complex aerosol
nitroglycerin
