摘要
目的:探讨半枝莲对白血病细胞株K562/A02耐药性逆转能力的影响。方法:体外培养K562细胞,分别加入高三尖杉酯碱(HHT)、长春新碱(VCR)、阿霉素(ADM)3种药物得到耐药细胞株K562/A02,MTT比色法检测半枝莲含药血清对3种K562/A02耐药性逆转作用的影响。结果:不同浓度的半枝莲含药血清均能够逆转K562/A02细胞的多药耐药性。结论:半枝莲在一定程度上能够逆转肿瘤细胞的多药耐药性,提高对化疗药物的敏感性。
Objective： To study the effect of Herba Scutellariae Barbatae reversal the resistance of drug about leukemia cell line K562/A02. Methods：K562 ceils in vitro were added to the base homoharringtonine（HHT）, vincristine（VCR）, adriamycin （ADM）-resistant cell lines obtained three drugs K562/A02. MTY colorimetric assay the reversal effect of serum containing the three barbata K562/A02 resistance Results： Different concentrations of Scutellaria barbata extract K562/A02 cells were able to reverse multidrug resistance. Conclusion： Barbata can reverse the multidrug resistance of tumor cells to some extent and increase the sensitivity to chemotherapeutic drugs.
出处
《中医药导报》
2012年第5期88-89,共2页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
山东省优秀中青年科学家科研奖励基金课题(2008BS03008)
山东省中医药科技发展计划项目(2007-001)
关键词
半枝莲
耐药性
逆转作用
Barbata
Drug resistance
The role reversal
