摘要
对苦参及其有效成分在治疗失眠方面的研究进行文献分析。以苦参、苦参碱、氧化苦参碱、失眠症为检索词,检索中国全文期刊数据库(CNKI)近10年的文献;从失眠的病理及治疗用药,以及苦参及其有效成分的作用机制筛选和引用文献。检索文献452条,引用文献40条。睡眠的物质基础和内稳态调节失衡是引起失眠的主要病理,苦参及其有效成分可增加脑内具有镇静作用的递质而发挥治疗作用。苦参及其有效成分可通过血脑屏障、调节脑内神经递质,产生中枢镇静作用而治疗失眠症,其相关制剂的应用有待重视。
To make the analysis of literature about flavescens and its active ingredient in the treatment of insomnia. Search terms were flavescens, matrine, oxymatrine, insomnia. The full text journal database （CNKI） literature of the past ten years were retrieved, and then to select and reference literature from the pathology and treatment of insomnia medication, as well as the sophora flavescens and its active ingredients mechanism. Forty literatures were quoted among four hundred and fifty-two items. Material basis and the homeostatic regulation of sleep imbalances are the main pathological cause of insomnia. Flavescens and its active ingredients can increase the brain of a sedative neurotransmitters, and then perform the effect on insomnia. Flavescens and its active ingredient could pass through the blood-brain barrier, regulate neurotransmitters in the brain and result in central sedation, and then to perform the effect on insomnia. In further studies, flavescens and its related agents should be developed and application.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第11期284-288,共5页
Chinese Journal of Experimental Traditional Medical Formulae
