摘要
研究了可乐定对梭曼中毒的预防作用 .结果显示试管内可乐定仅在高浓度 ( 1 - 1 0 mmol· L-1)时对 Ch E产生抑制 ,在小鼠体内 1 mg·kg-1,ip时对脑 Ch E也只产生轻微的抑制 .给小鼠先 ip可乐定对梭曼中毒小鼠脑和全血 Ch E活性无明显影响 ,却使中毒小鼠惊厥发生率及死亡率显著下降 .育亨宾可以明显对抗可乐定对梭曼中毒的预防作用 .说明 α2 肾上腺素受体可能介导了可乐定对梭曼中毒的预防作用 .
Clonidine prophylactic action against soman intoxication was investigated. The results showed that clonidine itself inhibited the brain cholinesterase(ChE) activity only at high concentrations(1-10 mmol·L -1 ) in vitro, and didn′t inhibited the brain and blood ChE obviously at 1 mg·kg -1 ip in mice. The pretreatment of clonidine could not affect the brain and blood ChE activity of soman intoxicated mice significantly, but it could significantly suppressed the incidence of soman induced seizure and death. Yohimbine expressed obviously antagonistic action against the protective effect of clonidine in soman intoxication. It suggests that the α 2 adrenergic receptor activation mediate the protective action of clonidine against soman intoxication.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2000年第1期12-15,共4页
Chinese Journal of Pharmacology and Toxicology
关键词
梭曼中毒
可乐定
预防
soman
clonidine
yohimbine
cholinesterase
