左旋咪唑治疗复发性阿弗他溃疡的疗效观察被引量：1

下载PDF

导出

摘要目的观察左旋咪唑对复发性阿弗他溃疡的治疗效果。方法对104例复发性阿弗他溃疡患者随机分为治疗组(78例)和对照组(26例),治疗组应用口服左旋咪唑及地塞米松进行治疗,持续时间4周,每周动态观察治疗效果及不良反应,所有病例随访一年,期间复发者重复治疗一次;对照组仅给予口服维生素和地塞米松。结果左旋咪唑对所有复发性阿弗他溃疡患者有效,有效率为100%,对照组有效率为26.9%,两组在统计学上有显著性差异(P<0.01)。结论左旋咪唑治疗复发性阿弗他溃疡,疗效确切,无严重不良反应。

作者吴渺夷藕小平

机构地区浙江省第一医院北仑分院药剂科

出处《海峡药学》 2012年第5期212-213,共2页 Strait Pharmaceutical Journal

关键词复发性阿弗他溃疡左旋咪唑

分类号 R781.5 [医药卫生—口腔医学]

引文网络
相关文献

参考文献7

1李秉琦.口腔黏膜病学[M].北京:人民卫生出版社,2000.95.
2周海文,吴岚,周曾同.口腔黏膜病临床治疗Ⅵ. 复发性阿弗他溃疡的诊断与治疗[J].中华口腔医学杂志,2007,42(1):57-59. 被引量：77
3李奉华,刘虹,彭解英,肖水源.复发性阿弗他溃疡致病因素及机制的研究进展[J].中国现代医学杂志,2003,13(7):41-43. 被引量：44
4Boras VV,Lukac J,Brailo V,et al.Salivary interleukin-6 and tumo r necrosi s factor-alpha in patients with recurrent aphthous ulceration[J].J oral Patlhol Med,2006,35(4):241-3.
5Borra RC,Andrade PM,Silva ID,et al.The Thl/Th2 immune-type resp onse of t he recurrent aphthous ulceration analyzed by cDNA microarray[J].J oral pathol Med,2004,33(3):140-146.
6Lewkowicz N,Lewkowicz P,Kurnatowska A,et al.Innate immune system is impl icated in recurrent aphthous ulcer pathogenesis[J].J Oral Pathol Med,2003,3 2(8):475-481.
7Sun A,Wang JT,Chia JS.Levamisole can modulate the serum tumor necr osis fa ctor-alpha inpatients with recurrent aphthous ulcerations[J].J oral Path ol Med,2006,35(2):111-116.

二级参考文献27

1Porter SR,Scully C,Pedersen A.Recurrent apthous stomatitis.Crit Rev oral Biol Med,1998,9(3):306-321.
2Rogers RS 3rd.Recurrent aphthous stomatitis:clinical characteristics and associated systemic disorders.Semin Cutan Med Surg,1997,16(4):278-283.
3Rivera-Hidalgo F,Shulman JD,Beach MM.The association of tobacco and other factors with recurrent aphthous stomatitis in an US adult population.Oral Dis,2004,10(6):335-345.
4Shulman JD.An exploration of point,annual,and lifetime prevalence in characterizing recurrent aphthous stomatitis in USA children and youths.J Oral Pathol Med,2004,33(9):558-566.
5Zain RB.Oral recurrent aphthous ulcers/stomatitis:prevalence in Malaysia and an epidemiological update.J Oral Sci,2000,42(1):15-19.
6Kovac-Kovacic M,Skaleric U.The prevalence of oral mucosal lesions in a population in Ljubljana,Slovenia.J Oral Pathol Med,2000,29(7):331-335.
7Jainkittivong A,Aneksuk V,Langlais RP.Oral mucosal conditions in elderly dental patients.Oral Dis,2002,8:218-223.
8Boras VV,Lukac J,Brailo V,et al.Salivary interleukin-6 and tumor necrosis factor-alpha in patients with recurrent aphtous ulceration.J Oral Pathol Med,2006,35(4):241-243.
9Borra RC,Andrade PM,Silva ID,et al.The Th1/Th2 immunetype response of the recurrent aphtous ulceration analyzed by cDNA microarray.J Oral Pathol Med,2004,33 (3):140-146.
10Lewkowicz N,Lewkowicz P,Kurnatowska A,et al.Innate immune system is implicated in recurrent aphtous ulcer pathogenesis.J Oral Pathol Med,2003,32(8):475-481.