摘要
目的探讨胰岛素抵抗与子宫内膜癌发生的关系。方法收集68例子宫内膜癌(EC)患者及68例健康对照者标本,分别对其空腹血糖(FG)、空腹胰岛素水平(FIN)进行检测,对两组病例FG、FIN、胰岛素敏感指数(ISI)及体质指数(BMI)进行比较,分析胰岛素抵抗(IR)与EC患者生育特征的关系。结果两组FG、FIN、BMI及ISI差异均有统计学意义(t分别=2.86、-9.31、10.16、11.09,P均<0.05)。EC组IR阳性率(60.02%),显著高于对照组(17.65%)。EC患者IR的发生与BMI、有无生育史及排卵障碍相关(χ2分别=5.43、5.12,P均<0.05)。结论对代谢指征的良好控制可能为今后提高子宫内膜癌预后的研究提供新的方向。
Objective To evaluate the association between insulin resistance （IR） and endometrial carcinoma （EC）. Methods Sixty eight EC patients and 68 healthy patients were enrolled in this study. Fasting serum was analyzed for glucose and insulin. Fasting glucose （FG）, fasting insulin （FIN）, insulin sensitive index （ISI） and body mass index （BMI） were analyzed and compared between EC and healthy control group. Association between IR and reproductive and menstrual characteristics were evaluated. Results Compared with the control group,FG,FIN,ISI and BMI for EC group were significantly different （t=2.86,-9.31,10.16, 11.09,P〈0.05）. The prevalence of IR was much higher in EC group（60.02%） than that of the normal people （17.65%）. The presence of IR in EC patients was associated with BMI,nulliparity and chronic anovulation （X2=5.43,5.12,P〈0.05）. Conclusions Control of metabolic parameters may provide a promising way to improve EC prognosis.
出处
《全科医学临床与教育》
2012年第3期274-276,共3页
Clinical Education of General Practice
关键词
子宫内膜癌
胰岛素抵抗
体质指数
endometrial carcinoma
insulin resistance
body mass index
