摘要
目的研究开唇兰属植物齿唇兰A.lanceolatus、艳丽齿唇兰A.moulmeinensis和西南齿唇兰A.elwesii的总膏对高脂饮食联合链脲佐菌素(STZ)诱导的大鼠模型血脂四项和肾功能的影响。方法高脂饮食联合STZ诱导的大鼠模型,分别灌胃给予3种总膏,测定给药后大鼠血浆的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、肌酐(CRE)和尿素氮(BUN)。肾脏切片,进行病理学检查。结果与模型组比较,3种植物提取物中艳丽齿唇兰总膏对于改善血脂代谢和减少肌酐和尿素氮的综合影响最有效,差异具有统计学意义(P<0.05),其次是齿唇兰总膏。结论艳丽齿唇兰总膏可能具有较好的降血脂作用及改善糖尿病肾病并发症的作用。
Objective To investigate the effect of total extracts from three different species of A noectiochilus on blood lipid and renal function in diabetic rats induced by high lipid diet plus streptozocin（STZ）. Methods The total extracts were prepared from A. lanceolatus, A. moulmeinensis and A. elweslii, respectively. The rat models were established by high lipid diet plus STZ, and the model rats were given gastric gavage of three kinds of total extracts. Plsama lev- els of total cholesterol（TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C）, and high density lipoprotein cholesterol（HDL-C）, creatinine（CRE）, blood usea nitrogen（BUN） in rats were assayed. Renal morpho- logical examination was performed. Results On the whole, the total extracts from A. moulmeinensis showed the best effect on improving lipid metabolism and renal function, the differences being significant compared with the model group（P〈0.05 ）. Conclusion The total extract from A. moulmeinensis may be the active part for reducing blood lipid and improving renal function.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2012年第3期271-274,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金(81001628)
关键词
齿唇兰
艳丽齿唇兰
西南齿唇兰
高脂饮食
链脲佐菌素
血脂
肾功能
大鼠
A. lanceolatus
A. moulmeinensis
A. elweslii
High Lipid diet
Streptozocin
Blood lipid
Renal function
Rats
