摘要
目的:研究血清表皮生长因子(EGF)和表皮生长因子受体(EGFR)在鼻咽癌患者临床诊治中的临床应用价值。方法:测定鼻咽癌患者、慢性咽炎及正常健康组中EGF和EGFR的含量进行对比分析。结果:EGF和EGFR在鼻咽癌组中呈升高,明显高于慢性咽炎及正常健康组,差异均有统计学意义(P<0.05)。存在淋巴结转移的鼻咽癌病例组中EGF和EGFR明显高于无淋巴结转移的病例组,差异均有统计学意义(P<0.05)。在EGF和EGFR升高的鼻咽癌病例组中5年生存时间低于EGF和EGFR无升高的鼻咽癌病例组,差异均有统计学意义(P<0.05)。结论:血清中EGF和EGFR含量的检测可作为鼻咽癌早期诊断和临床分期,预后判断的理想的血清生物学标志物。
Objective：To study of serum epidermal growth factor（EGF） and epidermal growth factor receptor（EGFR） in patients with nasopharyngeal carcinoma in clinical diagnosis and treatment of clinical application.Methods：Determination of patients with nasopharyngeal carcinoma,chronic pharyngitis and normal healthy group in EGF and EGFR content were analyzed.Results：EGF and EGFR in nasopharyngeal carcinoma group was elevated,was significantly higher than that of chronic pharyngitis and the normal group,the differences were statistically significant（P0.05）.The presence of lymph node metastasis in nasopharyngeal carcinoma group in EGF and EGFR was significantly higher than that without lymph node metastasis group,the differences were statistically significant（P0.05）.In EGF and EGFR increased in nasopharyngeal carcinoma in the group of 5year survival time less than EGF and EGFR without elevation of nasopharyngeal carcinoma group,the differences were statistically significant（P0.05）.Conclusion：the serum levels of EGF and EGFR content detection can be used as nasopharyngeal carcinoma early diagnosis and clinical staging,prognostic ideal serum biological markers.
出处
《中国医药导刊》
2012年第5期875-876,共2页
Chinese Journal of Medicinal Guide
关键词
鼻咽肿瘤
表皮生长因子
表皮生长因子受体
Nasopharyngeal neoplasm
Epidermal growth factor
Epidermal growth factor receptor
