摘要
本文应用紫外分光光度法,对6名精神病患者口服氯氮平后的唾药浓度进行测定,计算其药动学参数。结果,药物在体内的经时过程符合二室开放模型。t_(1/2)α为1·78±0.363h,t_(1/2)β11.36±1.35h,在相同条件下的同一时间测定氯氮平的血药浓度(P)与唾药浓度(S)之比值为1:0.28,两种浓度的相关性r=0.98。
A uv-spectropnotometry for determinating the saliva concentration of Clozapinewas established.The saliva concentration of Clozapine received from six psychaticswere determined.After oral administration,the saliva concentration of lozapinewere well described by a two-compartment open model.t1/2α=1.78±0.363h(mean±SD),t_(1/2)β=11.36±1.35h(mean±SD).Under the same conditions and at the sametime,the ratio of the blood concentration to the saliva concentration wasabout 1:0.28,r=0.98.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1990年第2期58-59,共2页
Chinese Journal of Hospital Pharmacy
关键词
氯氮平
唾药浓度
分光光度法
Clozapine saliva concentration uv-spectrophotometry
