期刊文献+

不同药物洗脱支架治疗老年急性心肌梗死疗效观察 被引量:3

Effect of drug-eluting stents on the elderly patients with acute ST-segment elevation myocardial infarction
原文传递
导出
摘要 目的探讨老年ST段抬高型急性心肌梗死患者应用雷帕霉素洗脱支架与紫杉醇洗脱支架经皮冠状动脉介入治疗的安全性及有效性。方法 129例≥65岁ST段抬高型急性心肌梗死患者,随机分为雷帕霉素组68例和紫杉醇组61例,分别应用雷帕霉素洗脱支架与紫杉醇洗脱支架经皮冠状动脉介入治疗,分析2组患者冠状动脉靶血管特点、手术成功率及术后12个月主要不良心脏事件及术后9个月晚期管腔丢失和支架内再狭窄情况。结果手术成功率100%,2组术后9个月晚期管腔丢失和支架内再狭窄发生率差异均无统计学意义(P>0.05);2组术后12个月病死率及心肌梗死、靶血管重建、主要不良心脏事件、支架内血栓形成的发生率差异均无统计学意义(P>0.05)。结论老年ST段抬高型急性心肌梗死患者使用雷帕霉素或紫杉醇支架经皮冠状动脉介入治疗近期治疗效果和安全性均较可靠。 Objective To compare the efficacy and safety of primary percutaneous coronary intervention(PCI) with sirolimus-eluting stents and paclitaxel-eluting stents for the elderly patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A total of 129 STEMI patients aged 65 years or older underwent primary PCI were randomly divided into sirolimus group(n=68,sirolimus-eluting stents) and paclitaxel group(n=61,paclitaxel-eluting stents).Target vessel features,operation success rate,incidence of major adverse cardiac events in postoperative 12 months,the late luminal loss and restenosis in postoperative 9 months were assessed.Results The operation success rate was 100%.There were no significant differences in late luminal loss and restenosis in postoperative 9 months between two groups(P〉0.05).There were no significant differences in fatality rate,incidences of reinfarction,target vessel revascularization,major adverse cardiac events and stent thrombosis in postoperative 12 months between two groups(P〉0.05).Conclusion Sirolimus-eluting stents and paclitaxel-eluting stents may have similar short-term efficacy and safety in the elderly patients with STEMI.
出处 《中华实用诊断与治疗杂志》 2012年第6期531-533,共3页 Journal of Chinese Practical Diagnosis and Therapy
基金 国家自然科学基金(30901939)
关键词 急性心肌梗死 老年 经皮冠状动脉介入治疗 药物洗脱支架 Myocardial infarction elderly percutaneous coronary intervention drug-eluting stents
  • 相关文献

参考文献11

  • 1Cutlip D E, Windecker S, Mehran R, et al. Clinical end points in coronary stent trials: a case for standardized definitions[J]. Circulation,2007,115(17) : 2344-2351.
  • 2Laarman G J, Suttorp M J, Dirksen M T, et al. Paclitaxeb eluting versus uncoated stents in primary percutaneous coronary intervention[J]. N EnglJ Med,2006,355(11):1105-1113.
  • 3HofmaSH, OngAT, AokiJ, et aL One year clinicalfollow-up of paclitaxel eluting stents for acute myocardial infarction compared with sirolimus eluting stents[J]. Heart,2005,91(9): 1176-1180.
  • 4Forman D E, Cox D A, Ellis S G, et al. Long-term paclitaxel eluting stent outcomes in elderly patients[J]. Circ Cardiovasc Interv,2009,2(3) : 178-187.
  • 5Park K W, Cho Y S, Chung J W, et al. One year clinical and six month angiographie results of drug eluting stents for ST elevating acute myocardial infarction: real world comparison between sirolimus- and paclitaxel-eluting stents [J]. Int J Cardiol,2009,131(3) ;350-355.
  • 6Violini R, Musto C, de Felice F, et al. Maintenance of long- term clinical benefit with sirolimus-eluting stents in patients with ST-segment elevation myocardial infarction 3-year results of the SESAMI (sirolimus-eluting stent versus bare-metal stent in acute myocardial infarction) trial[J]. J Am Coil Cardiol,2010,55(8) : 810-814.
  • 7de la Torre-Hernclndez J M, Alfonso F, Hernrindez F, et al. Drug eluting stent thrombosis: results from the multicenter Spanish registry ESTROFA (Estudio Espanol sobre Trombosis de stents Farmacoactivos)[J]. J Am Coll Cardiol,2008,51(10) : 986-990.
  • 8Hao P P, Chen Y G, Wang X L, et al. Efficacy and safety of drug-eluting stents in patients with acute ST-segment-elevation myocardial infarction: a meta-analysis of randomized controlled trials[J]. Tex Heart Inst J,2010,37(5):516-524.
  • 9王苏,张京梅,赵秀清,张冬花,阙斌,阴赪茜,孙涛,陶英,李志忠,吕树铮.冠状动脉介入术后氯吡格雷抵抗及影响因素[J].中华实用诊断与治疗杂志,2010,24(9):844-845. 被引量:21
  • 10张文利,黄定.经皮冠状动脉介入雷帕霉素药物洗脱支架内血栓反复形成临床分析[J].中华实用诊断与治疗杂志,2011,25(11):1115-1116. 被引量:5

二级参考文献23

  • 1郝盼盼,陈玉国,张运.氯吡格雷抵抗相关因素的研究进展[J].心血管病学进展,2009,30(6):991-994. 被引量:21
  • 2潘静薇,魏盟,李京波,陆志刚,马士新,魏钧伯.急性心肌梗死患者住院期死亡相关因素变化分析[J].实用诊断与治疗杂志,2007,21(4):280-282. 被引量:8
  • 3中华医学会心血管病学分会.中华心血管病杂志编辑委员会、中国循环杂志编辑委员会、急性ST段抬高心梗诊断和治疗指南.中华心血管病杂志,2001,29(12):710-725.
  • 4Cutlip D E, W indecker S, Mehran R, et al. Clinical end points in coronary stent trials: a case for standardized definitions[J]. Circulation, 2007,115(17) :2344 -2351.
  • 5Thomas F L, Jan S, Franz R, et al. Drug eluting stent and coronary thrombosis[J]. Circulation, 2007,115 (3) : 1051- 1058.
  • 6Deedwania P, Kosiborod M, Barrett E, et al. Hyperglycemia and acute coronary syndrome: a scientific statement Srom the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabnlism[J]. Circulation, 2008,117(12) :1610- 1619.
  • 7Duk-Woo P, Seong Wook P, Kyoung-Ha P, et al. Frequency of/ and risk factors for stent thrombosis after drug eluting stem implantation during long term follow-up[J]. Am J Cardiol, 2006, 98 (3) : 352-356.
  • 8Iakovou I, Schmidt T, Bonizzoni E, et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug eluting stents[J]. JAMA,2005,293(17) :2126 -3210.
  • 9Cheneau E , Leborgne L , Mintz G S, et al. Predictors of subacute stent thrombosis: results of asystematic intravascular ultrasound study[J]. Circulation, 2003,108 (1) : 43-47.
  • 10Windecker S, Remondino A, Eberli F R, et al. Sirolimus-eluting and paclitaxel-eluting stents for coronary revascularization[J]. N Engl J Med,2005,353(7) :653-662.

共引文献31

同被引文献58

引证文献3

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部