摘要
目的探讨盐酸氨溴索在老年人胸部手术围术期的肺保护作用。方法收集我院心胸外科2008年1月至2011年5月收治的老年普通胸外科手术住院患者共130例，男性79例，女性51例，年龄60～78岁，平均（65．1±4．3）岁。按入组编号随机分为盐酸氨溴索组与对照组，每组65例，盐酸氨溴索组在围术期应用盐酸氨溴索2mg／kg静脉滴注、1次jd进行干预，而对照组不予盐酸氨溴索干预，分析两组患者肺部并发症发生情况、手术前后血气分析变化及住院时间。结果盐酸氨溴索组肺部并发症发生率9．23％（6／65），低于对照组24．62Yoo（16／65）（Х^2＝2．43，p=0．018）；手术前后盐酸氨溴索组氧分压（PaO2）分别为（61．32±8．65）mmHg（1mmHg=0．133kPa）、（95.07±13．62）mmHg，对照组分别为（62．11±8．83）mmμg、（80．37±10．46）mmHg；二氧化碳分压（PaCO2）盐酸氨溴索组手术前后分别为（44．15±5．52）mmHg、（37．28±4．06）mmHg，对照组分别为（44．39±5．17）mmHg、（40．73±4．51）mmHg；PaO2和PaCO2均较对照组改善（t=3．61、3．75，均P〈0.05）；且盐酸氨溴索组患者平均住院时间（12．14±0．29）d。短于对照组（15．85±0．62）d（t=3．41，P=0．036）。结论老年人胸部围术期应用盐酸氨溴索具有肺保护作用，可提高临床疗效、减少肺部并发症、改善呼吸功能，且缩短了住院时问，临床值得推广应用。
Objective To study the lung protection of ambroxol in general thoracic surgery perioperation for the elderly. Methods Totally 130 hospitalized patients aged （65.1±4.3） years in our hospital during general thoracic surgery were randomly divided into two groups： ambroxol intervention（2 mg/kg, intravenous drip, once/d） and control groups （n= 65 for each）. The incidence of pulmonary complications, changes of blood gas analysis before and after surgery and time of hospitalization were compared between the groups. Results The incidence of pulmonary complications was significantly lower in ambroxol intervention group than in control group （9.23% vs. 24.62%, P〈0.05）. Blood gas analysis results before and after surgery were improved in ambroxol intervention group（PaO2： （61.32±8.65） mm Hg, （95.07±13.62）mm Hg; PaCO2 ： （44. 15±5.52） mm Hg,（37.28±4.06）mm Hg] as compared with control group（PaO2： （62.11±8.83） mm Hg, （80.37±10.46）mm Hg; PaCO2： （44.39±5.17） mm Hg, （40.73±4.51）mm Hg] （t=3.61, 3.75, both P〈0.05）. The time of hospitalization was shorter in ambroxol intervention group than in control group （12.14±0.29） d vs. （15.85±0.62）d, t=3.41, P=0.036]. Conclusions Perioperative use of ambroxol in general thoracic surgery in the elderly is worthy of clinical application because of reduction of pulmonary complications and shortness of hospital stay.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2012年第6期498-499,共2页
Chinese Journal of Geriatrics
关键词
氨溴素
手术期间
胸外科手术
Ambroxol
Intraoperative period
Thoracic surgical procedures
