期刊文献+

颅脑超声对帕金森病的诊断价值 被引量:6

Predictive value of transcranial sonography in the diagnosis of Parkinson disease
下载PDF
导出
摘要 目的探索颅脑超声(TCS)对帕金森病(PD)的诊断价值。方法对78例PD患者(PD组)和60名正常人(正常对照组)进行TCS检查,观察中脑回声,并测量中脑黑质回声增强的面积及与中脑面积的比值(S/M)。将中脑黑质面积≥0.20cm2和S/M≥7.00%诊断为PD,记为阳性,中脑黑质面积<0.20cm2或S/M<7.00%记为阴性。结果 PD组78例中,阳性66例,阴性12例;正常对照组60名中,5名为阳性,55名为阴性(P<0.005)。TCS诊断PD的敏感度、特异度、阳性预测值、阴性预测值和准确率分别为92.96%(66/71)、82.09%(55/67)、84.61%(66/78)、91.67%(55/60)、87.68%(121/138)。结论 TCS对辅助诊断PD有一定价值。 Objective To observe the value of transcranial sonography(TCS) for diagnosing Parkinson disease(PD).Methods Totally 78 PD patients(PD group) diagnosed clinically and 60 normal controls(control group) underwent TCS.The area of hyperechogenicity substantia nigra and midbrain,hyper-substantia nigra/midbrain(S/M) were measured.The substantia nigra area ≥0.20 cm2 and S/M ≥7.00% leaded to a diagnosis of PD recorded as positive,the substantia nigra area 0.20 cm2 or S/M 7.00% leaded to negative.Results Sixty-six patients in PD group and 5 subjects in control group were judged as positive by TCS(P0.005).The sensitivity,specificity,positive predictive value,negative predictive value and accuracy in diagnosis of PD was 92.96%(66/71),82.09%(55/67),84.61%(66/78),91.67%(55/60) and 87.68%(121/138),respectively.Conclusion TCS is a valuable assistant tool in the diagnosis of PD.
出处 《中国医学影像技术》 CSCD 北大核心 2012年第6期1069-1071,共3页 Chinese Journal of Medical Imaging Technology
关键词 帕金森病 黑质 超声检查 Parkinson disease Substantia nigra Ultrasonography
  • 相关文献

参考文献16

二级参考文献100

  • 1吕如锋,郑子萍,伍国锋,张文渊.假性肥大性肌营养不良症患儿的超声、肌电图及病理活检研究[J].临床神经电生理学杂志,2008,17(4):240-242. 被引量:3
  • 2Berg D. In vivo detection of iron and neuromelanin by transcranial sonography-a new approach for early detection of substantia nigra damage [J].J Neural Transm, 2006,113 (6) :775-780.
  • 3Okawa M, Miwa H, Kajimoto Y, et al. Transcranial sonography of the substantia nigra in Japanese patients with Parkinson' s disease or atypical Parkinsonism: clinical potential and limitations [ J]. Intern Med, 2007,46(18) :1527-1531.
  • 4Bogdahn U, Beeker G, Winkler J, et al. Transeranial color-coded real-time sonography in adults [J].Stroke, 1990,21 (12) : 1680- 1688.
  • 5Becker G, Berg D. Neuroimaging in basal ganglia disorders: perspectives for transcranial ultrasound [J]. Mov Disord, 2001,16 ( 1 ) :23-32
  • 6Doepp F, Plotkin M, Siegel L, et al. Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson' s disease and essential tremor [J]. Mov Disord, 2008,23(3) :405-410.
  • 7Berg D, Merz B, Reiners K, et al. Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson' s disease [ J]. Mov Disord, 2005,20(3) :383-385.
  • 8Zecca L, Berg D, Arzberger T, et al. In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage [ J ]. Mov Disord, 2005,20 (10) :1278-1285.
  • 9Walter U, Wittstock M, Benecke R, et al. Substantia nigra echogenicity is normal in non-extrapymmidal cerebral disorders but increased in Parkinson's disease. J Neural Transm, 2002, 109: 191-196.
  • 10Godau J, Schweitzer KJ, Liepelt I, et al. Substantia nigra hypoechogenieity: definition and findings in restless legs syndrome. Mov Disord, 2007, 22: 187-192.

共引文献15

同被引文献59

  • 1吕璇,水丽敏,唐弘,吴逊,陈丽波.经颅超声在帕金森病诊疗中的研究进展[J].中国实验诊断学,2023,27(9):1115-1120. 被引量:1
  • 2李晨,何文,张惠琴,王立淑,张红霞,程令刚,杜丽娟,曹辰杰.经颅超声成像诊断帕金森病的临床应用价值[J].中华医学超声杂志(电子版),2013,10(6):461-464. 被引量:4
  • 3谭纪萍,王鲁宁,王莹.脑血管病变与阿尔茨海默病关系的病例对照研究[J].中国现代神经疾病杂志,2006,6(3):182-187. 被引量:1
  • 4Gelb DJ, Oliver E, Gilman S. Diagnostic criteria for Parkinson disease. Arch Neurol, 1999,56(1):33-39.
  • 5Gilman S, Wenning GK, Low PA, et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology, 2008,71(9):670-676.
  • 6Louis ED, Ford B, Lee H, et al. Diagnostic criteria for essential tremor: A population perspective. Arch Neurol, 1998,55(6):823-828.
  • 7Berg D, Siefker C, Becker G. Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findings. J Neurol, 2001,248(8):684-689.
  • 8Mehnert S, Reuter I, Schepp K, et al. Transcranial sonography for diagnosis of Parkinson's disease. BMC Neurol, 2010,10:9.
  • 9Lau?kaitéK, Rastenyté D, ?urkiené D, et al. Specificity of transcranial sonography in Parkinson spectrum disorders in comparison to degenerative cognitive syndromes. BMC Neurol, 2012,12:12.
  • 10Behnke S, Berg D, Naumann M, et al. Differentiation of parkinson's disease and atypical parkinsonian syndromes by transcranial ultrasound. J Neurol Neurosurg Psychiatry, 2005,76(3):423-425.

引证文献6

二级引证文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部