摘要
目的:总结国内外有关甲状腺癌(TC)相关危险因素的研究进展。方法:应用检索PubMed和CNKI医学期刊全文数据库检索系统,以"甲状腺癌、危险因素"为关键词,检索2001-01-2011-12有关文献。纳入标准:1)TC危险因素,2)引起TC发病率增加的疾病或状态,3)在TC中高表达的基因。根据标准,纳入分析53篇参考文献。结果:多种因素与TC发生有关,其中辐射暴露、碘摄入过量、TC的家族史是TC较明确的危险因素。年龄、性别、体质量、术前血清TSH值、血清TgAb值、良性甲状腺状态、桥本甲状腺炎等与TC关系密切,BRAF、RAS和RET/PTC等被认为与TC相关。大多研究认为甲状腺结节的大小与数目与TC的危险性无明显相关性。结论:TC是一种多种危险因素引起的疾病,明确危险因素,对于术前结节性质的判定具有重要作用。
OBJECTIVE： To summarize the progress in research of thyroid carcinoma risk factor. METHODS： With ＂thyroid carcinoma, risk factor＂ as key words, the literature was searched in Pubmed and CNKI Free Medical Journal databases between 2001-01 and 2011-12. Choice criteria： 1） risk factors of thyroid carcinoma. 2） diseases and conditions which can increase the incidence rate of thyroid carcinoma. 3） genes which highly expressed in thyroid carcinoma. Eventually,53 documents were internalized. RESULTS：Variety of factors associated with thyroid carcinoma. Radiation expo sure, excessive iodine intake, family history of thyroid carcinoma are the clear risk factors of thyroid carcinoma. Age, sex, weight, preoperative serum TSH level, serum TgAb level, benign thyroid conditions and Hashimoto＇s thyroiditis are closely related to thyroid carcinoma. BRAF,RAS,RET/PTC et al. are considered with thyroid carcinoma. The size and number of thyroid nodules have no significant correlation with thyroid cancer. CONCLUSIONS：Thyroid carcinoma is a disease caused by variety of risk factors. Learn more about risk factors of thyroid carcinoma will be useful in the diagnosis of thy roid nodules preoperative.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第10期791-795,共5页
Chinese Journal of Cancer Prevention and Treatment
关键词
甲状腺肿瘤
危险因素
综述文献
thyroid neoplasms
risk factor
review literature
