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阻塞性睡眠呼吸暂停综合征动物模型的建立方法 被引量：2

An animal model of obstructive sleep apnea syndrome
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摘要 阻塞性睡眠呼吸暂停综合征(OSAS)因其高发病率和对人体多个系统的严重危害,已成为近年来多学科研究的热点。英格兰牛头犬(Englishbulldog)〔1〕、中国广西陆川猪〔2〕及最近发现的新西兰肥胖的(New Zealand obese)小鼠〔3〕这些自发性OSAS动物模型由于来源相对困难。 Obstructive sleep apnea syndrome（OSAS） is endangering human health seriously now. We had re- viewed some typical animal model which had at least one OSAS character of intermittent hypoxia and/or hypercap- nia, upper airway obstruction and sleep structure disorder. However, all of these models could not simulate clini- cal and pathological features of OSAS completely. Establishing a suitable animal model to study OSAS and related diseases is very important.
作者 杨蕾 胡滢洁 张孝文
机构地区 广州医学院第一附属医院耳鼻咽喉头颈外科
出处 《临床耳鼻咽喉头颈外科杂志》 CAS CSCD 北大核心 2012年第12期569-572,共4页 Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词 阻塞性睡眠呼吸暂停综合征 低氧血症 高碳酸血症 上气道阻塞 睡眠紊乱 动物模型 obstructive sleep apnea syndrome hypoxia hypercapnia upper airway obstruction sleep disor- der animal model
分类号 R563.8 [医药卫生—呼吸系统]
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参考文献21

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二级参考文献14

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临床耳鼻咽喉头颈外科杂志
2012年 第12期

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