摘要
黄连素具有确切的降糖作用,而其降糖作用的量效研究集中于动物及细胞实验。本文通过系统回顾国内外关于黄连素在整体动物实验及细胞实验的降糖作用的量效研究。得出以下结论 :(1)动物实验中,剂量在40～200mg/kg之间,黄连素降糖作用具有量效关系;(2)细胞研究示,黄连素具有潜在肝毒性(浓度≥3μmol/L);(3)肠道可能是黄连素发挥作用的重要部位,可能导致细胞实验与动物实验剂量范围的差异。
Berberine has the exact hypoglycemic effect, and its hypoglycemic dose-effect studies have focused on animal and cell experiments. In this paper, a systematic review on a dose of the hypoglycemic effect of berberine in the animal and cellular experiments. In conclusion ： animal experiments show that the hypoglyeemic effect of berberine has dose-effect relationship between 40 mg/kg and 200 mg/kg; and cell researches show that berberine has the potential liver toxicity （ ≥3 μmol / L） ; intestine may be an important part of the berberine play a role, and may lead to the differences of the dose range between cell experiments and animal studies.
出处
《环球中医药》
CAS
2012年第6期469-472,共4页
Global Traditional Chinese Medicine
基金
国家重点基础研究发展计划(973计划)(2010CB530601)
关键词
黄连素
量效关系
中药
综述
实验
Berberine
Dose-effect relationship
Traditional Chinese medicine
Review
Experiment
