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黑升麻异丙醇提取物防治GnRHa疗程中低雌激素症状疗效分析 被引量：2

黑升麻异丙醇提取物防治GnRHa疗程中低雌激素症状疗效分析
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摘要 目的研究黑升麻异丙醇提取物改善GnRHa治疗子宫内膜异位症疗程中低雌激素症状的疗效。方法选择2009年3月至2011年8月于中山大学孙逸仙纪念医院手术后应用GnRHa治疗的子宫内膜异位症患者125例,分入4组:研究组口服黑升麻异丙醇提取物,研究1组49例,从注射GnRHa第一针起开始服用,20mg/次,2次/d;研究2组45例,从注射GnRHa第二针开始口服,20mg/次,2次/d;反加疗法组21例,从使用GnRHa第二针开始口服利维爱,2.5mg/d;对照组10例,不使用研究药物或反加治疗药物。比较各组间及组内从使用GnRHa第一针起每4周Kupperman评分及各单项评分之间的差异及各组间用药前后FSH,LH,E2之间的差异。结果注射GnRHa第一针时,各组Kupperman评分差异无统计学意义(P>0.05),注射GnRHa第一针后4周,研究1组Kupperman评分,潮热出汗评分显著低于其他各组同期评分,差异有统计学意义(P<0.05)。注射GnRHa第一针后8周和12周,研究1和2组,反加疗法组Kupperman评分,潮热出汗评分均低于同期对照组,差异有统计学意义(P<0.05)。和反加疗法组比较,研究1和研究2组潮热出汗评分差异无统计学意义(P>0.05)。治疗后研究1和研究2组FSH、LH、E2与对照组相比差异无统计学意义(P>0.05)。结论 GnRHa治疗子宫内膜异位症疗程中,黑升麻异丙醇提取物从注射第一支GnRHa就开始使用,可以预防出现明显的潮热出汗症状。
作者 谢梅青 李扬志 王良岸 洪宇 陈冬梅 李春花
机构地区 中山大学孙逸仙纪念医院妇产科
出处 《中国实用妇科与产科杂志》 CAS CSCD 北大核心 2012年第6期457-459,共3页 Chinese Journal of Practical Gynecology and Obstetrics
关键词 黑升麻 促性腺激素释放激素激动剂 反向添加治疗 子宫内膜异位症 cimicifuga racemosa/black cohosh gonadotropin-releasing hormone agonlsts （GnRHa） add-back therapy en-dometriosis
分类号 R711 [医药卫生—妇产科学]
  • 相关文献

参考文献15

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二级参考文献13

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共引文献21

同被引文献23

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引证文献2

二级引证文献15

中国实用妇科与产科杂志
2012年 第6期

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