摘要
目的:用小鼠和大鼠对双氯芬酸钾(DK)原粉进行镇痛、抗炎的药效作用及急性毒性评价。方法 角叉菜胶致大鼠足跖肿胀法,二甲苯致小鼠耳廓肿胀法,热板法及扭体法。结果:抗炎试验结果显示,单次口服DK5.0～20.0mg·kg-1对角叉菜胶所致大鼠足跖肿胀的抑制作用显著(P<0.05或,P<0.01),镇痛试验结果显示,单次口服DK2.5～10.0mg·kg-1对小鼠热板法和扭体法呈显著或非常显著性镇痛作用(P<0.05或P<0.01),其抗炎和镇痛作用均明显强于阳性对照药扑炎痛。同时,对DK原粉的急性毒性试验结果显示,给予小鼠灌胃的LD50为(160.04±43.49)mg·kg-1,与腹腔注射途径所得LD50(182.58±30.64)mg·kg-1无显著差异。
OBJECTIVE: Pharmacodynamics and acute toxicity on diclofenac potassium(DK) were studied with mice and rats.METHODS:Carrageenin induced paw edema of rats and ear edema of mice;pains in writhing model and hot plate method.RESULTS:The anti inflammatory experimental results showed that DK had evidently inhibition in carrageenin induced paw edema of rats and ear edema of mice,a single dose between 5 10.0 mg·kg -1 when administered orally(P<0.05 or P<0.01).The results of analgesic experiments showed that DK remarkably inhibited pains in writhing model and hot plate method in mice between 2.5 10.0 mg·kg -1 when administere orally.The anti inflammatory effect and analgesic were superior to Benorilate.This study also evaluated acute toxicity of DK.The results showed that LD 50 with DK po in mice was 160.04±43.49 mg·kg -1 ,no significant difference comparable with DK ip(182.58±30.64)mg·kg -1 .
出处
《华西药学杂志》
CAS
CSCD
北大核心
2000年第1期27-29,共3页
West China Journal of Pharmaceutical Sciences
关键词
双氯芬酸钾
扑炎病
抗炎作用
镇痛作用
Diclofenac potassium
Anti inflammatory effect
Analgesic
LD 50
