摘要
目的评价度洛西汀治疗糖尿病足病疼痛的有效性和安全性。方法将42例糖尿病足病疼痛患者随机分为试验组（21例）和对照组（21例），对照组予降糖、营养神经等常规治疗，试验组在常规治疗的基础上加用度洛西汀60mg，每日1次，采用视觉模拟评分法（VAS）对疼痛进行评定，观察两组患者治疗前和治疗4周后疼痛改善情况。结果两组患者治疗后疼痛均有明显减轻。试验组总有效率为100．0％，对照组总有效率为80．9％，试验组疗效优于对照组，差异有统计学意义（P〈0．05）。结论度洛西汀治疗2型糖尿病足病疼痛是一种有效的方法，且有较好的安全性和耐受性。
Objective To evaluate the efficacy and safety of Duloxetine treatment with pain in diabetic foot. Methods 42 patients with pain in diabetic foot were divided into two groups. Patients in treatment group（ n = 21 ） were treated by combination of routine treatment and duloxetine 60 mg once dai- ly. Patients in control group（ n = 21 ） were treated by routine treatment： insulin, trophic nerve and so on. Using visual analysis scale（VAS） to assess the level of pain and observe the improvement of pain between two groups after treatment. Results Two groups of patients showed significant improvement of pain after treatment,the pain was significantly reduced. The total effective rate was 100.0% in the treatment group and 80.9% in the control group,the effect of treatment group was significantly better than the control group（ P 〈 0.05 ）. Conclusion The short - term study of Duloxetine on pain in diabetic foot is an effective way, and have good safety and tolerability.
出处
《临床内科杂志》
CAS
2012年第5期335-336,共2页
Journal of Clinical Internal Medicine
