摘要
目的观察长春瑞滨联合顺铂治疗三阴性乳腺癌(TNBC)的疗效和毒副反应。方法入组27例TNBC患者,均给予长春瑞滨联合顺铂化疗,化疗2周期后评价疗效和毒副反应。结果 27例晚期TNBC中,CR 1例(3.7%),PR 8例(29.6%),SD 15例(55.6%),PD 3例(11.1%),总有效率为33.3%,疾病控制率为88.9%。主要毒副反应为骨髓抑制和消化道反应,均可耐受。结论长春瑞滨联合顺铂治疗TNBC疗效较好,毒副反应较轻。
Objective To evaluate the efficacy and toxicities of vinorelbine combined with cisplatin in the treatment of triple-negative metastatic breast cancer （TNBC）. Methods Twenty seven patients with TNBC received the chemotherapy of vinorelbine combined with cisplatin. The efficacy and toxicities were evaluated after 2 cycles of chemotherapy. Results Of the 27 cases, CR was obse,＇ved in the 1 case （3.7%）, PR in the 8 cases （29.6%）, SD in the 15 cases （55.6%）, PD in the 3 cases （ 11.1% ） ,the response rate was 33.3%, the disease control rate was 88.9%. The main toxicities were marrow suppression and gastrointestinal reaction, and they were tolerable. Conclusion Vinorelbine combined with cisplatin is effective in the treatment of TNBC, and the toxicities are mild.
出处
《肿瘤基础与临床》
2012年第3期214-216,共3页
journal of basic and clinical oncology
关键词
长春瑞滨
顺铂
三阴性乳腺癌
vinorelbine
eisplatin
triple-negative metastatic breast cancer
