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内质网应激及未折叠蛋白反应通路研究进展 被引量：5

Research progress on endoplasmic reticulum stress and unfolded protein response pathway
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摘要 目前，内质网应激（Endoplasmic reticulumstress，ERS）及未折叠蛋白反应（Unfolded protein response，UPR）通路是毒理学研究中的热点。当毒物进入机体后，将影响内质网等细胞器的结构和功能，从而干扰和破坏机体的内稳态，引起暂时性或持久性的病理反应，甚至危及生命。
作者 周雪琼 贺凌飞 余日安
机构地区 广东药学院公共卫生学院劳动卫生与环境卫生学系(广东省分子流行病学重点实验室) 广东药学院附属第一医院
出处 《中国职业医学》 CAS 北大核心 2012年第3期264-267,共4页 China Occupational Medicine
基金 广东省自然科学基金资助项目(9151022401000003) 广东药学院师资队伍建设基金资助项目(广药[2008]154)
关键词 内质网应激 未折叠蛋白反应 需肌醇酶1 蛋白激酶样内质网激酶 转录激活因子6
分类号 R114 [医药卫生—卫生毒理学]
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参考文献25

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二级参考文献23

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共引文献15

同被引文献39

  • 1尹恝,潘速跃,周亮,吕田明,罗一峰,陆兵勋.海洛因海绵状白质脑病病理分析[J].南方医科大学学报,2007,27(6):881-883. 被引量：7
  • 2Donghong Zhang,Yequn Chen,Xina Xie,Jianlan Liu,Qingjie Wang,Wei Kong,Yi Zhu.Homocysteine activates vascular smooth muscle cells by DNA demethylation of platelet-derived growth factor in endothelial cells[J]. Journal of Molecular and Cellular Cardiology . 2012 (4)
  • 3Siyu Chen,Yan Ding,Weiwei Tao,Wenxiang Zhang,Tingming Liang,Chang Liu.Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1[J]. Food and Chemical Toxicology . 2012 (9)
  • 4Aikaterini Tsaousi,Helen Williams,Cressida A. Lyon,Victoria Taylor,Amanda Swain,Jason L. Johnson,Sarah J. George.Wnt4/β-Catenin Signaling Induces VSMC Proliferation and Is Associated With Intimal Thickening[J]. Circulation Research . 2011 (4)
  • 5XiaoHua Liu,Jing Shen,Rui Zhan,XingXing Wang,XiaoMing Wang,ZhiQing Zhang,Xue Leng,ZhiHua Yang,LingJia Qian.Proteomic analysis of homocysteine induced proliferation of cultured neonatal rat vascular smooth muscle cells[J]. BBA - Proteins and Proteomics . 2008 (2)
  • 6Chakrabarti, Anirikh,Chen, Aaron W.,Varner, Jeffrey D.A review of the mammalian unfolded protein response. Biotechnology and Bioengineering . 2011
  • 7Perez Jessica,Torres Rebecca A,Rocic Petra,Cismowski Mary J,Weber David S,Darley-Usmar Victor M,Lucchesi Pamela A.PYK2 signaling is required for PDGF-dependent vascular smooth muscle cell proliferation. American journal of physiology. Cell physiology . 2011
  • 8涂露霞,方唯意,刘真,李欣,何英,谢思明,姚开泰.慢病毒介导的siRNA靶向干扰EIF4G1鼻咽癌稳定细胞株的建立[J].南方医科大学学报,2009,29(5):844-847. 被引量：8
  • 9张叶,蒋旭超,钱海,马静,陆荣柱.内质网应激与金属毒作用机制关系的研究进展[J].环境与健康杂志,2010,27(10):922-925. 被引量：5
  • 10杨征,邱敏.丹参酮ⅡA的心血管作用及机制研究进展[J].中国动脉硬化杂志,2011,19(4):372-374. 被引量：36

引证文献5

二级引证文献36

中国职业医学
2012年 第3期

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