摘要
目的:探讨宫颈癌的发病因素,为宫颈癌的防治研究提供可靠依据。方法:收集120例子宫颈癌患者新鲜病灶组织,用HPV分型基因芯片检测系统对组织标本进行HPV16、HPV18的分型检测,同时统计分析初次性生活的年龄、阴道分娩次数等临床相关信息。结果:HPV阳性115例,阳性率95.8%,其中HPV16阳性85例(70.8%);HPV18阳性18例(15%);HPV16+18阳性12例(10%)。初次性生活的年龄≤20岁的女性宫颈癌发病率高于初次性生活的年龄>20岁的女性有统计学意义(P<0.05),阴道分娩次数≥3次的女性宫颈癌发病率高于分娩次数<3次的女性有统计学意义(P<0.05)。结论:该组资料的HPV16,HPV18阳性率达95.83%,子宫颈癌与HPV感染密切相关。初次性生活年龄≤20岁,阴道分娩次数≥3次也是宫颈癌发病的高危因素。
Objective：explore the risk factors of cervical cancer, For the prevention and control of the cervical cancer research to provide reliable basis. Methods： Collecte fresh lesions tissue in 120 cases of cervical cancer patients; use HPV genotyping chip detection system to test the tissue samples; Statistical analysis the age of first sexual activity ,frequency of vaginal delivery. Results： The HPV - positive rate is 95.8% , HPV16 -positive rate is 70.8% ;HPV18 -positive rate is 15% ;HPV 16 ＋ 18 positive rate is 10%. The female with the age of first sexual activity ≤20 years old has higher incidence of cervical cancer than the female with the age of first sexual activity 〉 20 years old woman, it is statistically significant （ P 〈 0. 05）. women with vaginal delivery times 〉13 times has higher incidence of cervical cancer than women with vaginal delivery times 〈3 times. It is statistically significant（P 〈 0. 05 ）. Conclusions ： The HPV - positive rate is 95.83%. Cervical cancer is closely related with HPV infection. Age of first sexual activity ≤20 years old, vaginal delivery times≥3 times are risk factors for cervical cancer.
关键词
宫颈癌
病因学
研究
Cervical cancer
Etiology
Research
