摘要
目的观察并对比NP方案(长春瑞滨联合顺铂)和PF方案(顺铂+5-Fu)治疗晚期食道癌的临床疗效。方法将58例晚期食道癌患者随机分为NP方案组和PF方案组,每组29例。NP方案组采用长春瑞滨联合顺铂化疗,PF组采用顺铂联合5-Fu化疗,以3周为一个化疗周期,2个周期后评价两组疗效及安全性。结果 NP方案组有效率为48.27%(14/29),PF方案组有效率为37.93%(11/29),NP方案组有效率明显高于PF方案组,差异具有统计学意义(P<0.05)。主要毒副反应为骨髓抑制和胃肠道反应,但均可耐受,两组在骨髓抑制率方面差异无统计学意义,但消化道反应方面PF组明显高于NP组,差异具有统计学意义(P<0.05)。结论 NP方案治疗晚期食道癌化疗,无论在临床疗效还是毒副作用方面,均明显优于PF方案;NP方案疗效确切,毒副作用可耐受,值得临床推广应用。
Objective To observe and compare the clinical efficacy and toxicity of NP Scheme（combi- nation of vinorelbine and cisplatin） and PF Scheme（ combination of cisplatin and fluorouracil） in the treatment of advanced esophageal carcinoma. Methods Patients of NP group were treated with Vinorelbine combinded cisplatin, while patients of PF group were treated with cisplatin eombinded fluorouracil. Every trentment period lasted two weeks, amd all of them were treated two periods. After two treatment periods, clinical efficacy and tox- icity of the two group were evaluated. Results After two treatment periods, all patients were valuable for re- sponse. The responserate of the NP group was 48.27% （14/29） ,while he PF group 37.93% （11/29） ,there was statistical significance between the responserate of the two group （P 〈 O. 05 ）. The main toxicities were mar- row suppression and pernicious vomiting, and the rate of pernicious vomiting PF group was much higher than that of PF group with statistical significance. Conclusion The combination of vinorelbine and eisplatin is a fea- sible, well-tolerated and active scheme in treatment of advanced esophageal carcinoma compared to the combi- nation of cisplatin and fluorouracil.
出处
《中国实用医药》
2012年第13期24-25,共2页
China Practical Medicine
关键词
晚期食道癌
长春瑞滨
顺铂
5-FU
联合化疗
Advanced esophageal carcinoma
Vinorelbine
Cisplatin
5-Fluorouracl
Combind chemotherapy
