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细胞自噬及其在肾脏疾病中的作用 被引量：4

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摘要 自噬（autophagy）是保持细胞内物质合成与分解代谢平衡,维持细胞器更新的重要生物学过程.近十年来随着自噬相关基因和相关标志蛋白的发现以及检测手段的进步,自噬的研究不断取得新的突破.细胞自噬不仅在细胞分化、生长、发育、老化等生理过程中有重要作用,在应激和疾病中,如内质网（ER）应激、氧化应激和自由氧离子（ROS）产生、神经元退行性疾病、微生物感染、肿瘤、肾病中同样起了重要作用.
作者 魏凯 顾乐怡
机构地区 上海交通大学医学院附属仁济医院肾脏科
出处 《中国中西医结合肾病杂志》 2012年第5期454-456,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
基金 国家自然科学基金资助项目(No.30971363) 上海市自然科学基金资助项目(No.08ZR1413200)
关键词 细胞自噬 肾脏疾病 氧化应激 生物学过程 退行性疾病 微生物感染 代谢平衡 物质合成
分类号 R692 [医药卫生—泌尿科学]
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参考文献34

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同被引文献40

  • 1Wu L, Feng Z, Cui S, et al. Rapamycin upregulates autophagy by inhibiting the mTOR - ULK1 pathway, resulting in reduced podo- cyte injury. PloS one ,2013,8 (5) : e63799.
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引证文献4

二级引证文献14

中国中西医结合肾病杂志
2012年 第5期

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