摘要
目的：探讨DOG1蛋白在胃肠道间质瘤（GISTs）中的表达及意义。方法：在光镜下观察GISTs的组织学特点,并采用免疫组化EnVision法检测DOG1在65例GISTs中的表达。结果：48例肿瘤来源于胃的GISTs中DOG1、CD117、CD34、α-SMA、Des和S-100的表达率分别为89.6%、79.2%、68.8%、33.3%、10.4%、14.6%;17例来源于肠道,其中DOG1、CD117、CD34、α-SMA、Des和S-100的表达率分别为88.2%、64.7%、70.6%、35.3%、11.8%和11.8%。16例CD117阴性的GISTs病例中有13例表达DOG1,7例DOG1阴性的病例中有3例表达CD117。42例（65%）患者随访3~33个月,其中26例病情缓解或无变化,12例肿瘤发生复发或转移,4例死亡。结论：DOG1是诊断GISTs的有用标志物,尤其对CD117阴性的GISTs患者有较高辅助诊断价值。
Objective To investigate the expression and significance of DOG1 in gastrointestinal stromal tumors（GISTs）.Methods The histological characteristic of GISTs was studied microscopically.The expressions of DOG1 on 65 cases of GISTs were tested by EnVision immunostaining.Results The expression rate of DOG1,CD117,CD34,α-SMA,Des and S-100 in 48 cases of GISTs from stomach was 89.2%,79.2%,68.8%,33.3%,10.4% and 14.6%,respectively.The expression rate of DOG1,CD117,CD34,α-SMA,Des and S-100 in 17 cases of GISTs from intestinal tract was 88.2%,64.7%,70.6%,35.3%,11.8% and 11.8%,respectively.Thirteen among 16 cases of GISTs negative for CD117 were positive for DOG1 while 3 among 7 cases of GISTs negative for DOG1 were positive for CD117.Forty-two cases（65%） were followed-up by 3-33 months.Twenty-six cases were relieved or unchanged,12 cases were relapsed or metastasized and 4 cases were dead.Conclusion DOG1 is a useful marker for GISTs,especially for GISTs negative for CD117.
出处
《诊断学理论与实践》
2012年第2期145-148,共4页
Journal of Diagnostics Concepts & Practice
