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结直肠癌微卫星不稳定性检测的临床病理意义及方法 被引量：5

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摘要 结直肠癌微卫星不稳定性(MSI)检测具有多重临床病理意义。MSI是指DNA甲基化或基因突变致错配修复基因缺失,从而导致微卫星重复序列长度的改变。散发性MSI结直肠癌多位于近端结肠,易伴发肠内及肠外其他器官多发性肿瘤,预后较好但对化疗药物5-氟尿嘧啶疗效欠佳。同时,MSI检测可用于诊断Lynch综合征。此外,免疫组化法也可作为检测肿瘤细胞中错配修复蛋白缺失的一种辅助方法。MSI检测是结直肠癌分子分型的基础,可以从分子遗传学角度加深对结直肠癌及癌前病变的认识了解。本文对结直肠癌MSI检测的临床病理意义、检测指征及检测方法进行简要介绍,以促进这一检查技术在临床及病理学实践中的应用。
作者 方园 王鲁平
机构地区 北京军区总医院病理科 安徽医科大学研究生学院
出处 《诊断病理学杂志》 CSCD 北大核心 2012年第3期227-230,共4页 Chinese Journal of Diagnostic Pathology
关键词 MSI检测 错配修复 DNA甲基化 胚系突变 结直肠癌
分类号 R735.37 [医药卫生—肿瘤]
  • 相关文献

参考文献38

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二级参考文献27

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共引文献7

同被引文献45

  • 1马俊丽,曾珊.错配修复基因和结肠癌的关系[J].中南大学学报（医学版）,2014,39(2):190-194. 被引量：13
  • 2许良中,杨文涛.免疫组织化学反应结果的判断标准[J].中国癌症杂志,1996,6(4):229-231. 被引量：1368
  • 3丁振,顾国利.遗传性结直肠癌的体系结构和诊治进展[J].中华结直肠疾病电子杂志,2013,2(4):184-190. 被引量：5
  • 4房殿春.胃癌发生的分子基础及防治[J].中国实用内科杂志,2005,25(12):1058-1060. 被引量：2
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  • 7Natasha Watson,Fabienne Grieu,Melinda Morris,Jennet Harvey,Colin Stewart,Lyn Schofield,Jack Goldblatt,Barry Iacopetta.??Heterogeneous Staining for Mismatch Repair Proteins during Population-Based Prescreening for Hereditary Nonpolyposis Colorectal Cancer(J)The Journal of Molecular Diagnostics . 2007 (4)
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引证文献5

二级引证文献22

诊断病理学杂志
2012年 第3期

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