摘要
[目的]比较观察不同剂量布托啡诺配伍丙泊酚应用于无痛肠镜麻醉的效果.[方法]171例择期行肠镜检查患者,随机分为三组.A组给予5 μg/kg,B组予10 μg/kg,C组予20 μg/kg的布托啡诺,三组均配伍丙泊酚1.8~2.5 mg/kg.观察并记录用药前（T0）、用药后2 min（T1）及术毕（T2）患者的收缩压（SBP）、舒张压（DBP）、心率（HR）、呼吸频率（RR）及脉搏氧饱和度（SpO2）及相关项目,行术后VAS评分,观察不良反应发生情况.[结果]三组T1时点SBP、DBP、HR、RR及SpO2均较T0时点降低（P〈0.05）,C组的SBP、HR、RR及SpO2较A组、B组下降更为明显（P〈0.05）,术毕即T2时点A组和B组SBP、DBP、HR、RR及SpO2均恢复到T0水平（P〉0.05）,C组SBP、DBP及HR仍较术前低（P〈0.05）.A组入镜时间、手术操作时间较B组及C组长（P〈0.05）,丙泊酚的总用量亦较B组及C组多（P〈0.05）,但术后清醒时间较C组短（P〈0.05）,与B组无统计学差异（P〉0.05）.A组术后VAS评分高于B组及C组（P〈0.05）.A组术中体动多于其余两组（P〈0.05）.A组和B组恶心呕吐、眩晕及嗜睡的发生率均较C组低（P〈0.05）.[结论]布托啡诺配伍丙泊酚用于无痛肠镜麻醉安全有效,10 μg/kg的布托啡诺剂量较为合适,对循环、呼吸影响小,可降低手术难度,不影响术后清醒,减轻术后疼痛,不明显增加不良反应发生率.
[Objective] To compare the effects of different doses of butorphanol combined with propofol used in painless enteroscopy. [Methods] Totally 117 patients scheduled for enteroscopy were randomly divided into group A, group B and group C. Group A was given butorphanol 5μg/kg and propofol 2.0-2.5mg/kg. Group B was given butorphanol 10μg/kg, while group C was given butorphanol 20μg/kg. SBP, DBP, HR, RR and SpO2 and other parameters before medication（T0 ）, 2min after medication（T1 ） and after operation（T2 ） were observed and recorded. VAS was performed after operation. The incidence of side effects was observed. [Results] Compared with To, SBP, DBP, HR, RR and SpO2 of three groups at T1 decreased（ P〈0.05）. Compared with group A and B, SBP, HR, RR and SpO2 of group C at T1 decreased more significantly（ P〈 0.05）. SBP, DBP, HR, RR and SpO2 of group A and group B at T2 recovered to those at To （ P 〉0.05）. Compared with before the operation, SBP, DBP and HR of group C at T2 still declined（ P〈d0.05）. Compared with group B and group C, the insertion time of enteroscope and operation time prolonged（ P 〈0.05）. The total dose of propofol in group A was more than that in group 13 and group C（ P〈 0.05）. The recovery time in group A was shorter than that in group C, but there was significant difference between group A and group B（ P〉0.05）. VAS score of group A after the operation was higher than that in group B and group C（ P〈0.05）. Intraoperative b＇ody movement of group A was more than the other groups（ P〈0.05）. The incidence of nausea, vomiting, dizzy and drowsiness in group A and group B was lower than that in group C（ P〈0.05）. [Conclusion]Butorphanol combined with propofol used in painless enteroscopy is safe and effective. Bu- torphanol 10μg/kg is proper and has little effect on circulation and respiration and no impact on the postopera-tive recovery, and can decrease the operation difficulty, alleviate postoperative pain, but not increase the inci-dence of adverse reactions obviously.
出处
《医学临床研究》
CAS
2012年第5期847-849,共3页
Journal of Clinical Research
