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miRNAs联合CA19-9对胰腺癌的诊断效能 被引量：3

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摘要 目的研究血清miRNAs(miR-16)联合CA19-9对胰腺癌的诊断效能。方法收集45例慢性胰腺炎患者、45例胰腺癌患者和30例健康人作对照,采用实时逆转录-多聚酶链反应方法检测血浆miR-16表达水平和临床检测糖链抗原19-9(CA19-9),分析miR-16、CA19-9及其二者联合对胰腺癌的诊断效能。结果 miR-16在血浆中含量胰腺癌>慢性胰腺炎(P<0.05),慢性胰腺炎组与健康对照组差异无统计学意义;miR-16联合CA19-9与miR-16、CA19-9单独诊断比较,miR-16与CA19-9联合可显著提高诊断胰腺癌的敏感性和特异性,LR+均>20,LR-均<0.2。结论 miR-16联合CA19-9可提高胰腺癌的诊断效能。
作者 王玉彬 孙丽丽 王晓雪
机构地区 辽宁医学院附属第一医院胃肠外科 辽宁医学院附属第一医院超声科 锦州康宁医院超声科
出处 《军医进修学院学报》 CAS 2012年第7期772-774,共3页 Academic Journal of Pla Postgraduate Medical School
关键词 胰腺癌 血清miRNAs 糖链抗原19-9
分类号 R735.9 [医药卫生—肿瘤]
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参考文献7

二级参考文献89

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共引文献44

同被引文献56

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  • 6Resel Folkersma L,Olivier Gómez C,San José Manso L. Immunomagnetic quantification of circulating tumoral cells in patients with prostate Cancer:clinical and pathological correlation[J].{H}Archivos Espanoles de Urologia,2010,(01):23-31.
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  • 8Snozek CL,Mascarenhas RC,O'kane DJ. Use of cyst fluid CEA,CA19-9,and amylase for evaluation of pancreatic lesions[J].{H}CLINICAL BIOCHEMISTRY,2009,(15):1585-1588.
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引证文献3

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军医进修学院学报
2012年 第7期

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