摘要
目的 探讨乳腺癌 (BC)合并派杰氏病 (PD)的流行病学、临床、病理特点、诊治和预后。方法 统计 195 8～ 1997年经手术和病理证实的乳腺癌合并派杰氏病 34例 ,从发生率、发病年龄、发病趋势、临床表现、分期和病理、诊断、治疗和预后等方面加以分析。结果 乳腺癌合并派杰氏病在乳腺癌中的发生率为 0 .9% ,可分为乳头病变组和乳腺肿块组 ,高发年龄 35～ 5 5岁 ,近年来就诊人数下降 ,治疗采取以手术为主的综合治疗。乳头病变组经病理证实 ,腋窝淋巴结阳性率、转移率均为 2 6 .7% ;5 ,10 ,2 0年生存率分别为 93.1%、78.1%和 6 7.0 %。乳腺肿块组经病理证实 ,腋窝淋巴结阳性率 5 2 .6 % ,远处转移率 42 .1% ;5 ,10 ,2 0年生存率分别为 6 0 .5 %、5 3.8%和 5 3.8%。结论 乳腺派杰氏病作为乳腺癌的一种特殊类型可与乳腺癌同时存在 ,病变局限于乳头的患者的预后优于合并乳腺包块者。
Objective To better understand the clinical and pathological features, diagnosis, treatment and prognosis of Paget′s disease accompanying breast cancer.Methods From 1958 to 1997, 34 such patients were operated and pathologically confirmed. Results Breast cancer combined with Pagat′s disease accounted for 0.9% of the total number of breast cancer patients treated in the same period of time. The mean age of patients was 47.3 years, and the mean duration of symptoms was 23.9 months. The patients received combination treatment with surgery as the major treatment modality. Among patients with nipple change as the first symptom, 26.7% of them had positive axillary nodes. The rate of metastasis was 26.7% as confirmed by surgical pathology. The 5 , 10 , and 20 year survival rate was 93.1%, 78.1% and 67.0%, respectively. Among those with palpable mass as the first symptom, metastasis to the axillary lymph nodes occurred in 52.6% of the cases, and distant metastasis in 42.1% of the cases. The rate of 5 ,10 and 20 year survival rate was 60.5%, 53.8% and 53.8%, respectively.Conclusion Paget′s disease,as a special form of breast cancer,may accompany cancer inside of the breast. In patients whose disease is confined to the nipple, their prognosis is better than those accompanied by palpable mass in the breast.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2000年第1期64-66,共3页
Chinese Journal of Oncology
