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阿托伐他汀联合尼可地尔治疗冠状动脉慢血流的临床研究 被引量：10

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摘要 目的通过对伴有胸痛症状的冠状动脉慢血流(CSF)患者临床资料进行分析,观察阿司匹林、尼可地尔及阿托伐他汀对CSF的疗效及血浆脂联素(APN)、超敏C反应蛋白(hs-CRP)的影响。方法经冠状动脉造影(CAG)诊断为CSF且伴有胸痛的患者35例,患者知情同意,给予阿司匹林100mg1次/d,尼克地尔5mg3次/d,阿托伐他汀20mg1次/晚。采取自身前后对照方法,观察治疗3个月后患者胸痛症状改善程度,以及APN及hs-CRP水平的变化。结果经治疗患者胸痛症状明显改善,有效率82%;经治疗血浆APN水平较前明显升高;hs-CRP水平较前明显减低,前后比较有统计学差异(P<0.05)。结论他汀联合尼可地尔对缓解CSF患者的胸痛症状疗效显著,可显著提高CSF患者的血浆APN水平,减低血浆hs-CRP水平。
作者 常快乐 王海昌 孙璐 廉坤 陶凌
机构地区 解放军第三医院心内科 第四军医大学西京医院心脏内科
出处 《中华临床医师杂志（电子版）》 CAS 2012年第12期167-168,共2页 Chinese Journal of Clinicians(Electronic Edition)
基金 国家高技术研究发展计划("863"计划 2009AA02Z104)
关键词 冠状血管 脂联素 C反应蛋白质 阿托伐他汀钙 慢血流
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献9

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同被引文献67

  • 1Ekmekci A, Gllng:r Bfizcan KS, et al. Evaluation of coronary microvascular function and nitric oxide synthase intron 4a/b polymorphism in patients with coronary slow flow [ J ]. Coron Artery Dis,2013,24(6) :461-467.
  • 2Tambe AA, Demany MA, Zimmerman HA, et al. Angina pectoris and slow flow velocity of dye in coronary arteries--a new angiographic finding. Am Heart J, 1972, 84: 66-71.
  • 3Hawkins BM, Stavrakis S, Rousan TA, et al. Coronary slow flow-- prevalence and clinical correlations. Circ J, 2012, 76: 936-942.
  • 4Ekmekci A, G ti ngOr B, Ozcan KS, et al. Evaluation of coronary microvascular function and nitric oxide synthase intron 4a/b polymorphism in patients with coronary slow flow. Coron Artery Dis, 2013, 24: 461-467.
  • 5Mangieri E, Macchiarelli G, Ciavolella M, et al. Slow coronary flow: clinical and histopathological features in patients with otherwise normal epicardial coronary arteries. Cathet Cardiovasc Diagn, 1996, 37: 375-381.
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  • 8Celebi H, Catakoglu AB, Kurtoglu H, et al. The relation between coronary flow rate, plasma endothelin-1 concentrations, and clinical characteristics in patients with normal coronary arteries. Cardiovasc Revasc Med, 2008, 9: 144-148.
  • 9Yucel H, Ozaydin M, Dogan A, et al, Plasma concentrations of asymmetric dimethylarginine, nitric oxide and homocysteine in patients with slow coronary flow. Scandinavian J Clinical & Laboratory Investigation, 2012, 72: 495-500.
  • 10Madak N, Nazh Y, Mergen H, et al. Acute phase reactants in patients with coronary, slow flow phenomenon. Anadolu Kardiyol Derg, 2010, 10: 416-420.

引证文献10

二级引证文献45

中华临床医师杂志（电子版）
2012年 第12期

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