摘要
喹诺酮类抗菌药抗菌谱广,在临床上广泛应用于各种感染的治疗。喹诺酮类药物可通过阻断拓扑酶的生理功能继而干扰细菌的复制,从而起到抗菌的作用。也正是由于其广泛应用,近年来此类药物的耐药现象严重,且机制多样。综述了喹诺酮类药物的作用机制、耐药机制及其研究进展。
Quinolones have potential and broad antimicrobial activity on gram-positive and -negative bacteria in clinic, respectively. They could interfere the duplication of bacteria by blocking the physiologic function of DNA gyrase and DNA topoisomerase IV. So quinolones have been used worldwide against a variety of infections. As a result of their frequent use, bacterial resistance to quinolones has gradually developed and limited their therapeutic efficacy in infections. This article reviews the antibacterial and resistance mechanisms of quinolone based on the recent research advances.
出处
《药物评价研究》
CAS
2012年第3期199-203,共5页
Drug Evaluation Research
基金
江苏省省级科技创新与成果转化专项引导资金项目(BE2008672)
关键词
喹诺酮类药物
耐药性
耐药机制
quinolones
drug resistance
mechanisms of resistance
