摘要
目的非甾体抗炎药和传统阿片类药物在术后镇痛中的效果。方法 126例骨科择期手术后分别给予非甾体抗炎药、传统阿片类镇痛药和生理盐水等用于术后镇痛,视觉模拟评分法观察患者疼痛程度及恶心、呕吐、呼吸抑制等不良反应的发生。结果术后1,2,4,8,12 h视觉模拟评分,2个给药组间差异无统计学意义(P>0.05),但评分明显低于生理盐水组,差异有统计学意义(P<0.05)。给药组能尽早下地活动,精神状态好于生理盐水组,传统阿片镇痛组恶心高于其他2组,2个给药组嗜睡反应高于生理盐水组,差异均有统计学意义(P<0.05)。结论非甾体抗炎药和传统镇痛药物均有较好的术后镇痛效果,非甾体抗炎药不良反应少于传统镇痛药。
Objective To investigate the effects of non-steroidal anti-inflammatory drugs（NSAIDs） and opiods in attenuating postoperative pain.Methods One hundred and twenty-six patients after undergoning elective surgery were randomized to receive NSAIDs,opiods or saline separately.Observed outcomes included pain evaluation by visual analogue scale（VAS） and the incidences of nausea,vomit and respiratory depression.Results VAS scores in NSAIDs group and opiods group were both significantly higher than that in saline group（P0.05）,whereas it did not differ significantly between NSAIDs group and opoids group at 1,2,4,8,12 h postoperatively（P0.05）.Patients in NSAIDs group and opiods group ambulated earlier and had a better mental state than those in saline group（P0.05）.The incidence of nausea and vomit was significantly higher in opiods group than in the other groups（P0.05）.The incidences of somnolence in NSAIDs group and opiods group were both significantly higher than those in saline group（P0.05）.Conclusion Both NSAIDs and opiods were effective in relieving postoperative pain.Furthermore,NSAIDs had less adverse effects than opiods.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2012年第6期417-419,共3页
The Chinese Journal of Clinical Pharmacology
