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缺电子Rh-BINAP催化剂催化氢化富电性底物的机理研究(英文)

Mechanistic study on hydrogenation of electron-rich substrates with electron-deficient Rh-BINAP catalyst
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摘要 合成了4种富电性的脱氢α-氨基酸衍生物,将缺电子催化剂Rh-3,5-CF3-(R)-BINAP用于这几种底物的不对称氢化反应中.讨论了底物上取代基及空间位阻对对映选择性的影响. Four electron-rich α-acetamidocinnamic acid derivatives were prepared and used as substrates in the asymmetric hydrogenation catalyzed by electron-deficient Rh-3, 5-CF3-（ R）- BINAP. Influence of the electronic properties of substituted groups in the substrates and their steric hindrance on the enantioselectivity of the product were discussed.
作者 黄碧玉 吴海臣 杨镜奎
机构地区 中国科学院研究生院化学与化学工程学院 中国科学院高能物理研究所
出处 《中国科学院研究生院学报》 CAS CSCD 北大核心 2012年第4期571-575,共5页 Journal of the Graduate School of the Chinese Academy of Sciences
基金 Supported by the Project of the National Natural Science Foundation of China(20972159) the President Fund of GUCAS
关键词 富电性底物 缺电子催化剂 不对称氢化 机理 electron-rich substrates electron-deficient Rh-BINAP catalyst asymmetric hydrogenation mechanism
分类号 O62 [理学—有机化学]
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中国科学院研究生院学报
2012年 第4期

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