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肺腺癌中Pim-3和P21^(waf1)蛋白表达的研究 被引量：3

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摘要 目的:检测肺腺癌和正常肺组织中Pim-3、P21waf1的表达,探讨两者表达异常在肺腺癌发生、发展中的作用。方法:采用免疫组化Envision法检测45例肺腺癌和20例正常肺组织中Pim-3和P21waf1蛋白的表达并分析其与临床病理特征的关系。结果:45例肺腺癌组织中Pim-3和P21waf1蛋白的阳性表达水平均显著高于正常肺组织组(P<0.05)。肺腺癌组中Pim-3蛋白的阳性表达水平与肿瘤的大小、分化程度、TNM分期、淋巴结转移均有显著统计学意义(P<0.05)。P21waf1蛋白阳性表达水平与肺腺癌的分化程度相关(P<0.05),中、低分化组均显著高于高分化组(P<0.05)。Pim-3蛋白与P21waf1蛋白在肺腺癌间表达无相关关系(r=0.146,P>0.05)。结论:Pim-3、P21waf1与肺腺癌的发生、发展密切相关。
作者 陈文 刘永春 任占平
机构地区 广西医科大学第五附属医院 广西医科大学第五附属医院
出处 《实用医学杂志》 CAS 北大核心 2012年第12期2020-2022,共3页 The Journal of Practical Medicine
关键词 肺肿瘤 PIM-3 P21WAF1 免疫组化
分类号 R734.2 [医药卫生—肿瘤]
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参考文献8

  • 1Marina Zemskova,Michael B,Lill Y. p53-dependent induction Of prostate cancer cell senescence by the PIM1 protein kinase[J].Molecular Cancer Research,2010,(08):1126-1141.
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二级参考文献22

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实用医学杂志
2012年 第12期

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