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纳米晶体药物研究进展 被引量：26

Research progress in nanocrystal drugs
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摘要 纳米晶体技术能够有效提高难溶性药物的溶解度和溶出速度,从而提高其口服生物利用度,降低食物效应,是难溶性药物递送系统最具潜力的研究方向。在调研国内外文献的基础上,本文就纳米晶体药物的特点、组成、制备技术、临床应用及纳米效应的定量表达等方面的研究进展进行综述。 Nanocrystal technology can effectively improve the solubility and dissolution rate for many poorly-water-soluble drugs, thereby significantly improving its oral bioavailability and decreasing the food effect. Hence, this technology has become one of the most vital research directions for drug delivery systems. Based on the literature at home and abroad, the recent progress in nano- crystal drugs in phannaeeutics is reviewed in this paper, including the characteristics, composition, preparation technology, clinical application and the quantitative expression of nanometer effect for the insoluble drugs.
作者 郑爱萍 石靖
机构地区 军事医学科学院毒物药物研究所药物制剂研究室 国家食品药品监督管理局药品审评中心
出处 《国际药学研究杂志》 CAS 2012年第3期177-183,共7页 Journal of International Pharmaceutical Research
基金 国家重大新药创制科技重大专项综合性新药研究开发技术大平台资助项目(2011ZX09301-03)
关键词 纳米晶体 难溶性药物 溶解度 生物利用度 nanocrystals poorly-water-soluble drugs solubility bioavailability
分类号 R943 [医药卫生—药剂学]
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参考文献30

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二级参考文献36

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共引文献6

同被引文献354

引证文献26

二级引证文献135

国际药学研究杂志
2012年 第3期

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