摘要
[目的]了解浙江省富硒地区人群的健康状况,初步掌握硒对人群健康的影响。[方法]采用生态对比研究的方法,在富硒与非富硒调查地区共选择322名成人居民作为研究对象,进行患病情况调查及实验检测分析。[结果]富硒调查地区2008年冠心病和脑卒中的发病率分别为6.23/10万、177.69/10万,均低于非富硒调查地区的19.74/10万和223.68/10万;富硒地区人群谷胱甘肽过氧化物酶平均水平为261.49U/L,明显高于非富硒地区的248.99U/L(t=2.64,P<0.05);富硒地区人群B淋巴细胞水平为9.33%,低于非富硒地区的11.18%(t=-4.00,P<0.05)。[结论]硒在减少心血管疾病患病率、抗肿瘤、免疫调节等方面具有重要作用。
[ Objective ] To evaluate the health status of population in selenium （Se）-rich areas of Zhejiang province to explore possible effects of selenium on health. [ Methods ] A comparative ecological study was conducted to compare the disease prevalence and laboratory examination results of 322 adult residents in Se-rich and non-Se areas. [ Results ] In 2008, the incidences of coronary heart disease and stroke were 6.23/105 and 177.69/105 respectively in the Se-rich areas, both of which were less than those in the non-Se areas （19.74/105 and 223.68/10s, respectively）. The average glutathione peroxidase concentration of population in the Se-rich areas was significantly higher than that in the non-Se areas （261.49 U/L vs. 248.99 U/L, t=2.64, P 〈 0.05）; but the B-lymphocyte concentration of population in the Se-rich areas was significantly lower than that in the non-Se areas （9.33% vs. 11.18%, t=-4.00, P〈0.05）. [ Conclusion ] Selenium plays an important role in cardiovascular disease control, antitumor and immunoregnlation, while its mechanisms need further study .
出处
《环境与职业医学》
CAS
北大核心
2012年第6期361-364,共4页
Journal of Environmental and Occupational Medicine
基金
浙江省科技厅计划项目(编号:2007C23042)
关键词
硒
谷胱甘肽过氧化物酶
免疫功能
冠心病
脑卒中
selenium
glutathione peroxidase
immune function
coronary heart disease
stroke
