摘要
目的:探讨老年男性脑梗死患者骨保护素(osteoprotegerin OPG)、骨钙素(osteocalcin OC)与颈动脉粥样斑块的关系。方法:对234例男性脑梗死患者行颈部血管彩超检查评估有无斑块,分为有斑块组和无斑块组,根据斑块性质分为稳定斑块组和不稳定斑块组,检测血浆OPG、OC水平。结果:Logistic回归分析发现OPG、OC与颈动脉斑块分别成正相关(OR=1.407,P<0.05)和负相关(OR=0.928,P<0.05)。稳定斑块组血浆OPG水平低于不稳定斑块组,而OC水平高于不稳定斑块组,差异均有统计学意义(P<0.05)。结论:老年男性OPG值越高,发生颈动脉粥样斑块的危险性越大,可能与不稳定斑块相关;OC可能具有抗动脉粥样斑块作用且与稳定斑块相关。
Objective： To study the relationship between carotid atherosclerotic plaque and serum osteoprotegerin,osteocalcin in the elderly male patients with cerebral infarction. Methods： 235 male patients with cerebral infarction were screened for carotid plaque by duplex color Doppler and then classified into plaques group and no plaques group.The stable plaques group and unstable plaques group were further classified,and the OPG and OC were measured. Results： The Logistic multiple regression analysis showed that the regression coefficients of OPG and OC were positive（OR=1.407,P0.05） and negative relatively（OR= 0.928,P0.05）,The level of OPG was lower in stability plaques group than that of unstable plaques group,the level of OC was higher in the stable plaques group than that in the instability plaques group,all the differences were statistically significant（P0.05）. Conclusion： The higher of the OPG value,the bigger of the atheromatous plaque occurrence rate,may relate with unstable plaques.The OC may fight against atherosclerosis and relate with stable plaques.
出处
《河南医学研究》
CAS
2012年第2期164-166,共3页
Henan Medical Research
关键词
骨保护素
骨钙素
颈动脉粥样斑块
脑梗死
osteoprotegerin
osteocalcin
carotid atherosclerotic plaque
cerebral infarction
