摘要
目的研究肺癌骨转移的相关临床因素。方法选取笔者所在医院收治的67例肺癌骨转移患者,回顾性研究其临床资料,分析骨转移情况及性别、年龄、病理分型、原发灶部位、转移类型及接受治疗方法与骨转移之间的关系。骨转移率采用Kaplan-Meier法计算。单因素分析采用Log-rank法,多因素分析采用Cox回归模型。结果本组患者显示70%以上的骨转移是在肺癌确诊后18个月内发生的,单因素和多因素分析均显示肺癌骨转移与病理分型及原发病灶手术治疗相关(P<0.05),肺小细胞癌和肺腺癌骨转移的风险大,肺鳞癌骨转移风险小,肺癌原发病灶手术治疗可显著降低骨转移风险。单因素分析还显示肺癌骨转移伴随其他脏器转移率明显较大(P<0.05)。结论肺癌骨转移与病理分型及原发灶手术治疗明显相关,临床上应密切观察和积极随访,及早诊断并争取手术治疗,预防骨转移发生。
Objective Analyse the related faclors with bone metastasis in patients with lung cancer. Methods Analyse the clinical data of all the patients with bone metastasis in primary lung cancer. The rate of bone metastasis was obtained by K-M method,the univariate analysis was obtained hy Logrank and muhivariate was obtained by analysis by Cox regression. Results Both univariate analysis and multivariate analysis showed that the histologic type and operative treatment were remarkable relative to bone metastasis in primary lung eaneer（P 〈 0.05）. Conclusion It＇s necessary to follow up closely in patients with lung cancer in order to diagnose bone metastasis early and apply operative treatment to decrease the rate of bone metastasis.
出处
《中国医药科学》
2012年第10期16-17,50,共3页
China Medicine And Pharmacy
关键词
肺癌
骨转移
单因素
多因素
Lung cancer
Bone metastasis
Univariate analysis
Multivariate analysis
