摘要
双膦酸盐类药物被广泛用于治疗骨质疏松、恶性肿瘤骨转移等相关的骨骼疾病,引起颌骨骨坏死是其严重的并发症。这种并发症或自然发生,或发生于简单牙槽外科手术后。本文报告1例静脉使用双膦酸盐类药物唑来膦酸(zoledronic acid)致上颌骨骨坏死病例,并结合文献,对双膦酸盐相关性颌骨坏死的发病机制、临床表现、预防和治疗进行讨论。
Bisphosphonate compounds are used to treat osteoporosis and malignant bone metastasis. Despite the benefits related to use of these medications, osteonecrosis of the jaws is a significant complication in a subset of patients receiving these drugs. This complication occurs either spontaneously or after a simple dento-alveolar surgery. Recently there was a patient who showed the features of bisphosphonate related osteonecrosis of the jaws （BRONJ） in our hospital. This article reported one typical case of osteonecrosis of the maxilla treated with Zoledronic acid and reviewed the relevant literature related to pathogenesis, clinical presentation as well as management and prevention of this new complication
出处
《上海口腔医学》
CAS
CSCD
北大核心
2012年第3期354-358,共5页
Shanghai Journal of Stomatology
关键词
双膦酸盐
颌骨
骨坏死
Bisphosphonates
Jaw
Osteonecrosis
