摘要
目的:优选补肾温肺微乳口服液的制备处方。方法:采用伪三元相图法优选微乳处方,测定其粒径,观察透射电镜视图,并对微乳进行初步物理稳定性考察。结果:优选处方为油相白术、防风、细辛挥发油,水相淫羊藿、黄芪、山茱萸等药材提取浓缩液(3 g·mL-1),表面活性剂Tween-80,助表面活性剂无水乙醇。电镜视图显示微乳呈类球形,平均粒径为(18.25±0.08)nm,多分散指数(PDI)平均值为0.212±0.02,制备的微乳物理稳定性良好。结论:处方中的挥发油可直接作为油相形成微乳,制备的微乳粒径分布均匀,性质稳定。
Objective： To optimize preparation prescription of Bushen Wenfei microemulsion oral liquid. Method： Microemulsion prescription was optimized by pseudoternary phase diagram method, particle size was measured, transmission electron microscopic ＇view was observed, and initial physical stability of microemulsion were investigated. Result： Optimum prescription was： volatile oil from Atractylodes macrocephala, Saposhnikovia divaricata and Asarum sieboldii as oil phase, extraction concentration liquid （3 g .mL^-1） of Epirnedium brevicornum, Astragalus mernbranaceus and Comus officinalis as water phase, Tween-80 as surfactant, ethanol as cosurfactant. Electron microscope view showed microemulsion was spherical, average particle size was （ 18.25 ± 0.08） nm, average PDI was 0. 212± 0.02, physical stability of prepared microemulsion was good. Conclusion： Volatile oil from the prescription could be oil phase to form microemulsion, particle size of prepared microemulsion distributed uniform with stable nature.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第13期34-36,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
湖南省中医药科研计划项目(2010117)
关键词
挥发油
微乳
伪三元相图法
volatile oil
microemulsion
pseudoternary phase diagram method
